721428-34-8

Basic information

• Product Name: 5-CHLOROMETHYL-3-(4-FLUORO-PHENYL)-[1,2,4]OXADIAZOLE
• Synonyms: 5-(Chloromethyl)-3-(4-fluorophenyl)-1,2,4-oxadiazole
• CAS NO: 721428-34-8
• Molecular Formula: C₉H₆ClFN₂O
• Molecular Weight: 212.61
• Mol File: 721428-34-8.mol
• Article Data: 15

Chemical Properties

• Melting Point: 31-32 °C(Solv: hexane (110-54-3))
• Boiling Point: 311.5±52.0 °C(Predicted)
• Appearance: /
• Density: 1.364±0.06 g/cm3(Predicted)
• PKA: -2.57±0.37(Predicted)
• CAS DataBase Reference: 5-CHLOROMETHYL-3-(4-FLUORO-PHENYL)-[1,2,4]OXADIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLOROMETHYL-3-(4-FLUORO-PHENYL)-[1,2,4]OXADIAZOLE(721428-34-8)
• EPA Substance Registry System: 5-CHLOROMETHYL-3-(4-FLUORO-PHENYL)-[1,2,4]OXADIAZOLE(721428-34-8)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 721428-34-8(Hazardous Substances Data)

Usage

Uses

5-Chloromethyl-3-(4-fluoro-phenyl)-[1,2,4]oxadiazole

Upstream product

• 22179-78-8 4-fluoro-benzamidoxime 
• 794554-75-9 C₉H₈ClFN₂O₂ 
• 456-06-4 4-fluorobenzoyl hydrazide 
• 1194-02-1 4-fluorobenzonitrile 
• 22179-78-8 (Z)-4-fluoro-N'-hydroxybenzimidamide 
• 74974-54-2 2-chloro-1,1,1-trimethoxyethane 
• 794554-75-9 C₉H₈ClFN₂O₂ 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 1062370-79-9 C₁₇H₁₀FN₃O₃ 
• 1229114-79-7 {5-chloro-2-[(3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl)-methoxy]-phenyl}-(phenyl)-methanone 
• 937665-70-8 (3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl)methylamine 

Relevant articles and documents

In vitro anti-TB properties, in silico target validation, molecular docking and dynamics studies of substituted 1,2,4-oxadiazole analogues against Mycobacterium tuberculosis

The alarming increase in multi- and extensively drug-resistant (MDR and XDR) strains of Mycobacterium tuberculosis (MTB) has triggered the scientific community to search for novel, effective, and safer therapeutics. To this end, a series of 3,5-disubstitu

Reactions of 3-(p-substituted-phenyl)-5-chloromethyl-1,2,4-oxadiazoles with KCN leading to acetonitriles and alkanes via a non-reductive decyanation pathway

The present work describes an unfamiliar reaction of 5-(chloromethyl)-3-substituted-phenyl-1,2,4-oxadiazoles with KCN affording trisubstituted 1,2,4-oxadiazol-5-ylacetonitriles and their parent alkanes, namely, 1,2,3-trisubstituted-1,2,4-oxadiazol-5-ylpro

Design, microwave assisted synthesis and characterization of substituted 1,2,4-oxadiazole analogues as promising pharmacological agents

Microwave assisted synthesis of a series of 3,5-disubstituted-1,2,4-oxadiazole analogues (3a-j) has been achieved between 5-(chloromethyl)-3-substituted phenyl-1,2,4-oxadiazoles (2a-j) and substituted benzophenone in presence of potassium carbonate in ace