72156-62-8Relevant articles and documents
Synthesis, characterization, and DNA binding and cleavage properties of copper(II)-tryptophanphenylalanine-1,10-phenanthroline/2,2′-bipyridine complexes
Reddy, Pulimamidi R.,Raju, Nomula,Satyanarayana, Battu
, p. 131 - 144 (2011)
The mononuclear dipeptide-based CuII complexes [Cu II(trp-phe)(phen)(H2O)] ClO4 (1) and [CuII(trp-phe)(bpy)(H2O)] ClO4 (2) (trp-phe=tryptophanphenylalanine, phen=1,10-phenanthrol
Late-stage construction of stapled peptides through Fujiwara-Moritani reaction between tryptophan and olefins
Liu, Jiang,Lu, Qi,Wang, Peng,Zeng, Wei,Zhu, Qing
supporting information, p. 11661 - 11664 (2021/11/12)
Herein, the first example of a palladium-catalyzed Fujiwara-Moritani reaction for olefination of tryptophan (Trp) residues, free from directing groups, was presented. The developed reaction proceeds efficiently for peptide modification, ligation and pepti
Solid-State Radical C?H Trifluoromethylation Reactions Using Ball Milling and Piezoelectric Materials
Ito, Hajime,Kubota, Koji,Lee, Joo Won,Pang, Yadong
supporting information, p. 22570 - 22576 (2020/10/21)
The application of piezoelectricity for the generation of trifluoromethyl (CF3) radicals is reported together with the development of a method for the mechanochemical C?H trifluoromethylation of aromatic compounds. As compared to conventional solution-based approaches, this mechanoredox C?H trifluoromethylation enables cleaner and more sustainable access to a wide range of trifluoromethylated N-heterocycles and peptides, which are important structural motifs in modern drug discovery. This study thus represents an important milestone for future applications of mechanoredox systems to medicinal and pharmaceutical science.