7217-59-6

Basic information

• Product Name: 2-METHOXYBENZENETHIOL
• Synonyms: Benzenethiol, 2-methoxy-;2-Methoxythiophenol 98%;2-METHOXYTHIOPHENOL 2-METHOXYBENZENETHIOL;2-METHOXYTHIOPHENOL / 2-MERCAPTOANISOLE;2-Mercaptoanisole, 2-Methoxybenzenethiol, Thioguaiacol;2-Methoxybenzene-1-thiol;Thiocatechol O-methyl ether;2-Methoxybenzenethiol,97%
• CAS NO: 7217-59-6
• Molecular Formula: C₇H₈OS
• Molecular Weight: 140.2
• EINECS: 230-605-7
• Product Categories: Phenol&Thiophenol&Mercaptan;Phenoles and thiophenoles
• Mol File: 7217-59-6.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 99 °C8 mm Hg(lit.)
• Flash Point: 204 °F
• Appearance: Clear yellow/Liquid
• Density: 1.152 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.077mmHg at 25°C
• Refractive Index: n20/D 1.591(lit.)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: H2O: insoluble
• PKA: 6.62±0.43(Predicted)
• Sensitive: Stench
• Stability: Moisture Sensitive
• BRN: 2042178
• CAS DataBase Reference: 2-METHOXYBENZENETHIOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHOXYBENZENETHIOL(7217-59-6)
• EPA Substance Registry System: 2-METHOXYBENZENETHIOL(7217-59-6)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-36/37/38
• Safety Statements: 26-36/37-37/39
• RIDADR: 3334
• WGK Germany: 3
• RTECS: DC1790000
• F: 10-13-23
• TSCA: T
• HazardClass: IRRITANT, STENCH
• Hazardous Substances Data: 7217-59-6(Hazardous Substances Data)

Usage

Chemical Properties

Different sources of media describe the Chemical Properties of 7217-59-6 differently. You can refer to the following data:
1. clear yellow liquid
2. Colorless to yellowish liquid; pungent, onion aroma.

Uses

Different sources of media describe the Uses of 7217-59-6 differently. You can refer to the following data:
1. 2-Methoxythiophenol is used in the synthesis of berberine-thiophenyl hybrids as multifunctional agents. Inhibition of acetylcholinesterase, butyrylcholinesterase and AB aggregation antioxidant activity.
2. 2-Methoxythiophenol was used in the synthesis of:(4S)-N-[(2S)-2-methy-3-(2-methoxyphenylthio)propanoyl]-4-phenyloxazolidin-2-one2-(4-fluorophenyl)-6-(2-methoxyphenylsulfanyl)imidazo[1,2-a]pyridine2-(2-methoxyphenylsulfanyl)benzoic acid

Aroma threshold values

Meaty type, very high strength odor, recommend smelling in a 0.10% solution or less.

Taste threshold values

Meaty sausage taste at 1 ppm in water.

General Description

2-Methoxythiophenol is a sulfur-containing compound that can be used as a flavoring agent.

InChI:InChI=1/C7H8OS/c1-8-6-4-2-3-5-7(6)9/h2-5,9H,1H3/p-1

Upstream product

• 17356-93-3 2-methoxy-benzenediazonium 
• 140-89-6 potassium ethyl xanthogenate 
• 13920-94-0 bis(2-methoxyphenyl)disulfide 
• 90-04-0 2-methoxy-phenylamine 
• 274-26-0 1,3-benzoxathiole 
• 578-57-4 2-bromoanisole 
• 2388-73-0 1-methoxy-2-(methylsulfanyl)benzene 
• 529-28-2 4-iodoanisol 
• 75-08-1 ethanethiol 
• 31836-28-9 thiocarbonochloridic acid O-(2-methoxy-phenyl) ester 
• 18619-21-1 <(2-Methoxyphenyl)thio>acetic acid 
• 248584-44-3 (3S,3aR,4S,6aR,9S,9aR,9bR)-4-Hydroxy-3-(2-methoxy-phenylsulfanylmethyl)-9-methyl-6-methylene-octahydro-azuleno[4,5-b]furan-2,8-dione 
• 7647-01-0 hydrogenchloride 
• 1071094-99-9 3-(2-methoxy-benzenesulfonyl)-2-phenyl-quinoline 

Downstream Products

• 126770-56-7 1-methoxy-2-[(2-methoxyphenyl)sulfanyl]benzene 
• 14065-23-7 1-methoxy-2-[(4-methoxyphenyl)thio]benzene 
• 18619-21-1 <(2-Methoxyphenyl)thio>acetic acid 
• 13920-94-0 bis(2-methoxyphenyl)disulfide 
• 71556-63-3 o-methoxybenzenesulfenyl chloride 
• 109963-06-6 S-(2-methoxyphenyl) ethanethioate 
• 2388-73-0 1-methoxy-2-(methylsulfanyl)benzene 
• 143745-63-5 2-<(2-methoxyphenyl)thio>-N-methylethanamine 
• 57275-17-9 2-(o-Methoxyphenylthio)-benzoic acid 
• 114615-19-9 6-Chloro-2-(2-methoxy-phenylsulfanyl)-3-nitro-benzoic acid 
• 118617-57-5 N-<(o-methoxyphenylthio)methyl>formamide 
• 121486-98-4 3-(N,N-dimethylamino)-2-(2-methoxyphenylthio)acrylaldehyde 
• 136436-89-0 N,N-dimethyl-3-(2-methoxyphenylthio)-3-phenylpropylamine 
• 1026230-45-4 C₂₆H₂₉N₃O₉S 

Relevant articles and documents

SINGLE-STEP SYNTHESIS METHOD OF ARYL THIOL AND APPLICATION THEREOF

The present invention relates to a single-step synthesis method of aryl thiol, and more specifically, to a method of synthesizing aryl thiol in a single-step by making aryl halide react with alkane dithiol in the presence of a transition metal catalyst. According to the present invention, a single-step synthesis method using the transition metal catalyst, the synthesis method which is capable of synthesizing aryl thiol from aryl halide at a high yield, can be provided. Various aryl halides may be applied to the synthesis method. Further, the synthesis method has advantages that an easily usable reagent may be used, operations are simple, and reactions can be performed under mild conditions. In addition, the synthesized aryl thiol may be used in the synthesis of advanced molecules such as diaryl sulfides and benzothiophenes.COPYRIGHT KIPO 2017

Copper-Catalyzed Direct Synthesis of Aryl Thiols from Aryl Iodides Using Sodium Sulfide Aided by Catalytic 1,2-Ethanedithiol

A copper-catalyzed direct and effective synthesis of aryl thiols from aryl iodides using readily available Na 2 S·9H 2 O and 1,2-ethanedithiol was described. A variety of aryl thiols were readily obtained in yields of 76-99%. In this protocol, Na 2 S·9H 2 O was used as ultimate sulfur source, and 1,2-ethanedithiol functioned as an indispensable catalytic reagent.

N-Acylhydrazones as inhibitors of PDE10A

Cyclic nucleotide phosphodiesterases (PDEs) are represented by a large superfamily of enzymes. A series of hydrazone-based inhibitors was synthesized and shown to be novel, potent, and selective against PDE10A. Optimized compounds of this class were efficacious in animal models of schizophrenia and may be useful for the treatment of this disease.