7220-81-7 Usage
Description
Aflatoxin B2 is a naturally occurring mycotoxin and food contaminant produced by various species of the mold Aspergillus. It is the dihydro derivative of aflatoxin B1 and belongs to the blue fluorescent family of bisfuranocoumarin mycotoxins. Aflatoxin B2 has a hexahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4, and 11. It is a likely pathogen that causes hepatocellular carcinoma and is highly carcinogenic. Aflatoxin B2 is found widely in nature in trace amounts, particularly in grains and nuts. It is an off-white powder and is one of the fungal metabolic products produced in food and feed contaminated by Aspergillus species.
Uses
Aflatoxin B2 is primarily known for its harmful effects on human and animal health, and its presence in food and feed is a major concern for food safety. However, it can be used in research and analysis for the following purposes:
Used in Research and Analysis:
Aflatoxin B2 is used as a reference compound for studying the toxic effects of mycotoxins on human and animal health. It helps in understanding the mechanisms of carcinogenesis and the role of aflatoxins in hepatocellular carcinoma.
Used in Food Safety Testing:
Aflatoxin B2 is used as an analytical standard for the development and validation of methods to detect and quantify aflatoxins in food and feed products. This helps in ensuring the safety and quality of food products and preventing the consumption of contaminated food.
Used in Environmental Monitoring:
Aflatoxin B2 can be used as an indicator of mold contamination in the environment, particularly in grains and nuts. Monitoring the presence of aflatoxins can help in assessing the risk of mycotoxin exposure and implementing preventive measures to reduce contamination.
Used in Agricultural Practices:
Aflatoxin B2 can be used to study the factors that contribute to mold growth and aflatoxin production in crops. This knowledge can help in developing strategies to minimize mold contamination and reduce the risk of aflatoxin exposure in agricultural products.
Safety Profile
Confirmed human carcinogen with experimental tumorigenic data. Poison by ingestion. Mutation data reported. When heated to decomposition it emits acrid smoke and fumes. See also various aflatoxins.
Incompatibilities
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.
Check Digit Verification of cas no
The CAS Registry Mumber 7220-81-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,2,2 and 0 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 7220-81:
(6*7)+(5*2)+(4*2)+(3*0)+(2*8)+(1*1)=77
77 % 10 = 7
So 7220-81-7 is a valid CAS Registry Number.
7220-81-7Relevant articles and documents
Kinetic and mechanistic investigations on reductions of aflatoxins by lactic acid
Shukla, Ram S.,Verma, Ramtej J.,Mehta, Daxa N.
, p. 2737 - 2741 (2002)
The kinetics of reduction of AFB1 to AFB2 and AFG1 to AFG2 by lactic acid has been investigated in dilute aqueous acidic solutions (pH 3.35-4.50) as a function of the concentrations of lactic acid, AFB1, AFG1 and hydrogen ion at 37°C. The rate of the reaction was found to be first order with respect to the concentrations of lactic acid and aflatoxins and independent on hydrogen ion concentration. The experimental results are interpreted in terms of mechanisms involving an initial formation of transient oxonium intermediate, which tends to polarize the olefinic (C=C) carbon, which in turn causes the hydride abstraction from α-carbon atom of lactic acid in rate determining step. The proposed mechanisms involve an overall transfer of two protons and two electrons from lactic acid to AFB1 and AFG1 to give the corresponding reduced less toxic products AFB2 and AFG2 and the oxidised product pyruvic acid.
