72216-04-7 Usage
Description
2-(2-Fluorophenyl)pyrrolidine is a chemical compound that features a pyrrolidine ring fused with a fluorophenyl group. This unique structure endows it with versatile chemical properties, making it a valuable component in various synthesis processes.
Uses
Used in Organic Synthesis:
2-(2-Fluorophenyl)pyrrolidine serves as a key intermediate in organic synthesis, facilitating the creation of a wide range of complex organic molecules. Its presence in these reactions often enhances the reactivity and selectivity of the synthesized products.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, 2-(2-Fluorophenyl)pyrrolidine is utilized as a crucial building block for the development of new drugs. Its unique structure allows for the design of molecules with specific biological activities, targeting a variety of therapeutic areas.
Used in Agrochemicals:
2-(2-Fluorophenyl)pyrrolidine is also employed in the agrochemical industry, where it is used as a precursor to develop novel pesticides and other crop protection agents. Its incorporation can lead to enhanced efficacy and selectivity in these applications.
Used in Dye Industry:
In the dyestuff industry, 2-(2-Fluorophenyl)pyrrolidine is used as an important raw material for synthesizing various dyes and pigments. Its distinctive structure contributes to the color properties and stability of the resulting dyes, making them suitable for different applications.
Check Digit Verification of cas no
The CAS Registry Mumber 72216-04-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,2,2,1 and 6 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 72216-04:
(7*7)+(6*2)+(5*2)+(4*1)+(3*6)+(2*0)+(1*4)=97
97 % 10 = 7
So 72216-04-7 is a valid CAS Registry Number.
InChI:InChI=1/C10H12FN/c11-10-4-2-1-3-9(10)8-5-6-12-7-8/h1-4,8,12H,5-7H2
72216-04-7Relevant articles and documents
Stereocomplementary Synthesis of Pharmaceutically Relevant Chiral 2-Aryl-Substituted Pyrrolidines Using Imine Reductases
Chen, Fei-Fei,Chen, Qi,Li, Bo-Bo,Xu, Jian-He,Zhang, Yu-Hui,Zheng, Gao-Wei,Zhou, Xin-Yi
, p. 3367 - 3372 (2020)
Exploring a collection of naturally occurring imine reductases (IREDs) identified two stereocomplementary IREDs with reducing activity toward sterically hindered 2-aryl-substituted pyrrolines. Using (R)-selective ScIR and (S)-selective SvIR, various chiral 2-aryl-substituted pyrrolidines with excellent enantioselectivity (>99% ee) were stereocomplementarily synthesized in good yield (60-80%), demonstrating the feasibility of IREDs for generating pharmaceutically relevant chiral 2-aryl-substituted pyrrolidine intermediates.
