72242-00-3

Basic information

• Product Name: 3-aminophencyclidine
• Synonyms: 3-aminophencyclidine
• CAS NO: 72242-00-3
• Molecular Formula: C₁₇H₂₆N₂
• Molecular Weight: 258.40174
• Mol File: 72242-00-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 400.7±28.0 °C(Predicted)
• Appearance: /
• Density: 1.065±0.06 g/cm3(Predicted)
• PKA: 8.08±0.20(Predicted)
• CAS DataBase Reference: 3-aminophencyclidine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-aminophencyclidine(72242-00-3)
• EPA Substance Registry System: 3-aminophencyclidine(72242-00-3)

Safety Data

• Hazardous Substances Data: 72242-00-3(Hazardous Substances Data)

Upstream product

• 77-10-1 Phencyclidine 
• 70227-29-1 3-nitrophencyclidine 

Downstream Products

• 76916-16-0 1-Phenyl-3-[3-(1-piperidin-1-yl-cyclohexyl)-phenyl]-thiourea 

Relevant articles and documents

Syntheses of Amine Derivatives of Phencyclidine

3-Aminophencyclidine (5) was synthesized by reduction of 3-nitrophencyclidine (3) using either H2 with Pd/C or Na2S in refluxing methanol.Attempts to isolate 4-aminophencyclidine (2), which we hoped to synthesize by hydrolysis of carbamate 15 which was isolated after reaction of amide 10 under Hofmann conditions employing bromine in CH3O(1-)/CH3OH at -40 deg C, were unsuccessful. 4-Aminomethylphencyclidine (18) was synthesized by LAH reduction of nitrile 13 as well as by reductive amination of aldehyde 20.Nitrile 13 and aldehyde 20 were synthesized from 4-bromophencyclidine (11) as was alcohol 26 which served as a precursor to 4-(2-aminoethyl)phencyclidine (19).Amine 19 was also synthesized by NaBH4 reduction of β-nitrostyrene 29 which was generated from aldehyde 20 by condensation with nitromethane using 1,5-diazabicycloundecene as the base catalyst followed by LAH reduction of resulting 4-(2-nitroethyl)phencyclidine (30).Mass spectra and 13C NMR spectra have been obtained on most of the phencyclidine derivatives.