722499-79-8

Basic information

• Product Name: 2-(R)-tert-butoxycarbonylamino-N-[2-(4-hydroxyphenyl)ethyl]-3-methylbutyramide
• Synonyms: 2-(R)-tert-butoxycarbonylamino-N-[2-(4-hydroxyphenyl)ethyl]-3-methylbutyramide
• CAS NO: 722499-79-8
• Molecular Weight: 336.431
• Mol File: 722499-79-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(R)-tert-butoxycarbonylamino-N-[2-(4-hydroxyphenyl)ethyl]-3-methylbutyramide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(R)-tert-butoxycarbonylamino-N-[2-(4-hydroxyphenyl)ethyl]-3-methylbutyramide(722499-79-8)
• EPA Substance Registry System: 2-(R)-tert-butoxycarbonylamino-N-[2-(4-hydroxyphenyl)ethyl]-3-methylbutyramide(722499-79-8)

Safety Data

• Hazardous Substances Data: 722499-79-8(Hazardous Substances Data)

Upstream product

• 51-67-2 tyrosamine 
• 22838-58-0 Boc-D-Val-OH 

Downstream Products

• 722499-86-7 (2S,5R)-2-(3,5-dibenzyloxy-4-methoxyphenyl)-3-[2-(4-hydroxyphenyl)ethyl]-5-isopropylimidazolidin-4-one 
• 722499-84-5 2-(R)-amino-N-[2-(4-hydroxyphenyl)ethyl]-3-methylbutyramide 
• 722499-88-9 (2S,5R)-2-(3,5-dibenzyloxy-4-methoxyphenyl)-3-(4-hydroxyphenethyl)-5-isopropyl-1-(2,2,2-trifluoroacetyl)imidazolidin-4-one 

Relevant articles and documents

Total synthesis of (-)-galanthamine by remote asymmetric induction

A pivotal intramolecular Michael addition to form a fused 5,7,5 ring system and the skeleton of (-)-galanthamine (1) was completely controlled by a remote chiral imidazolidinone auxiliary derived from D-phenylalanine (see scheme). This total synthesis of the allylic alcohol 1 avoids the corresponding enone narwedine, a highly allergenic intermediate in previous syntheses of 1.