72298-63-6 Usage
Description
Decanoyl-p-nitroanilide (DepNA) is a nitroaniline fatty acid amide that serves as a colorimetric substrate for measuring fatty acid amide hydrolase (FAAH) activity. It is a compound that allows for the fast and convenient assessment of FAAH activity through the release of the yellow colorimetric dye p-nitroaniline upon exposure to FAAH.
Uses
Used in Research and Diagnostics:
Decanoyl-p-nitroanilide is used as a colorimetric substrate for [measuring FAAH activity] because [exposure to FAAH results in the release of the yellow colorimetric dye p-nitroaniline, which can be easily detected and quantified using a 96 well plate spectrophotoometer].
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Decanoyl-p-nitroanilide is used as a research tool for [developing and testing inhibitors of FAAH], as understanding FAAH activity is crucial for the development of drugs targeting various conditions, including pain management and neurodegenerative diseases.
Used in Biochemical Assays:
Decanoyl-p-nitroanilide is used as a reagent in [biochemical assays] for [quantifying FAAH activity], providing a convenient and reliable method to study the enzyme's function and its role in various biological processes.
Check Digit Verification of cas no
The CAS Registry Mumber 72298-63-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,2,2,9 and 8 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 72298-63:
(7*7)+(6*2)+(5*2)+(4*9)+(3*8)+(2*6)+(1*3)=146
146 % 10 = 6
So 72298-63-6 is a valid CAS Registry Number.
72298-63-6Relevant articles and documents
Synthesis, antimicrobial evaluation, QSAR and in silico ADMET studies of decanoic acid derivatives
Kumar, Ashwani,Singh, Surender,Jain, Sandeep,Kumar, Parvin
, p. 191 - 204 (2011/10/09)
Various derivatives of decanoic acid (CD) have been synthesized and evaluated against Gram positive B. subtilis, S. aureus and Gram negative E. coli bacteria as well as against fungi C. albicans and A. niger. Quantitative structure activity relationship (QSAR) models for antimicrobial activities were developed using multiple linear regression and cross validated by leave one out (LOO) approach. QSAR studies indicated that activity against Gram positive bacteria was governed by lipophilicity of the compounds while topological steric nature of the molecule was deciding factor for antifungal activity. Further, in silico ADMET studies showed that compounds CD12, 19, 20 and 23 could be explored further for other activities.
