7232-21-5 Usage
Description
Metoclopramide HCl, also known as metoclopramide hydrochloride, is an orally bioavailable serotonin (5-HT) receptor 5-HT3 antagonist and a dopamine D2 receptor antagonist. It is a white solid that is used in the pharmaceutical industry for its antiemetic and antipsychotic properties. Metoclopramide works by blocking the action of serotonin and dopamine in the brain, which helps to reduce nausea and vomiting, as well as exhibiting antipsychotic effects.
Uses
Used in Pharmaceutical Industry:
Metoclopramide HCl is used as an antiemetic agent for the treatment of nausea and vomiting caused by various conditions, such as chemotherapy, radiation therapy, and surgery. It is particularly effective in inhibiting emesis induced by cisplatin and apomorphine in ferrets and dogs.
Metoclopramide HCl is also used as a D2DR inhibitor and an HTR3E inhibitor, which helps in the treatment of various psychiatric disorders and gastrointestinal motility issues.
Furthermore, Metoclopramide HCl is used as a dopamine D2 receptor antagonist, which aids in the management of symptoms related to gastrointestinal disorders, such as gastroesophageal reflux disease (GERD) and gastroparesis.
In addition to its antiemetic and antipsychotic applications, Metoclopramide HCl also exhibits reversible inhibition of human acetylcholinesterase (AChE), which can be beneficial in the treatment of certain neurological conditions.
Biochem/physiol Actions
D2 antagonist; 5-HT3 antagonist; antipsychotic; anti-emetic.
Clinical Use
Nausea and vomiting
Veterinary Drugs and Treatments
Metoclopramide has been used in veterinary species for both its
GI stimulatory and antiemetic properties. It has been used clinically
for gastric stasis disorders, gastroesophageal reflux,
to allow
intubation of the small intestine, as a general antiemetic (for parvovirus,
uremic gastritis, etc.), and an antiemetic to prevent or treat
chemotherapy-induced vomiting.
Drug interactions
Potentially hazardous interactions with other drugs
Ciclosporin: increased ciclosporin blood levels.
Metabolism
Metoclopramide undergoes first-pass hepatic metabolism.
It is excreted in the urine, about 85% of a dose
being eliminated in 72 hours, 20% as unchanged
metoclopramide and the remainder as sulfate or
glucuronide conjugates, or as metabolites. About 5% of a
dose is excreted in faeces via the bile.
Check Digit Verification of cas no
The CAS Registry Mumber 7232-21-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,2,3 and 2 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 7232-21:
(6*7)+(5*2)+(4*3)+(3*2)+(2*2)+(1*1)=75
75 % 10 = 5
So 7232-21-5 is a valid CAS Registry Number.
