72335-16-1

Basic information

• Product Name: 4-chloro-4-phenylbutyronitrile
• Synonyms: 4-chloro-4-phenylbutyronitrile
• CAS NO: 72335-16-1
• Molecular Weight: 179.649
• Mol File: 72335-16-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-chloro-4-phenylbutyronitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-4-phenylbutyronitrile(72335-16-1)
• EPA Substance Registry System: 4-chloro-4-phenylbutyronitrile(72335-16-1)

Safety Data

• Hazardous Substances Data: 72335-16-1(Hazardous Substances Data)

Upstream product

• 2046-18-6 4-phenylbutyronitrile 
• 5343-98-6 4-oxo-4-phenylbutanenitrile 
• 100-52-7 benzaldehyde 
• 24241-74-5 (+/-)-4-hydroxy-4-phenylbutanenitrile 
• 100-42-5 styrene 
• 107-14-2 chloroacetonitrile 

Relevant articles and documents

Copper-catalyzed radical ring-opening halogenation with HX

An efficient copper-catalyzed radical ring-opening halogenation with HX (aq) is described. This protocol features redox-neutral conditions, green halogen sources, and a broad substrate scope, providing practical access to distally chlorinated, brominated and iodinated alkyl ketones and alkyl nitriles with moderate to good yields. This journal is

Silver-Catalyzed C(sp3)-H Chlorination

A silver-catalyzed chlorination of benzylic, tertiary, and secondary C(sp3)-H bonds was developed. The reaction proceeded with as low as 0.2 mol % catalyst loading at room temperature under air atmosphere with synthetically useful functional group compatibility. The regioselectivity and reactivity tendencies suggest that the chlorination proceeded through a radical pathway, but an intermediate alkylsilver species cannot be ruled out.