72342-64-4

Basic information

• Product Name: methyl (3S)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-4-methylpentanoate
• Synonyms: methyl (3S)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-4-methylpentanoate
• CAS NO: 72342-64-4
• Molecular Weight: 275.304
• Mol File: 72342-64-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: methyl (3S)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-4-methylpentanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (3S)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-4-methylpentanoate(72342-64-4)
• EPA Substance Registry System: methyl (3S)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-4-methylpentanoate(72342-64-4)

Safety Data

• Hazardous Substances Data: 72342-64-4(Hazardous Substances Data)

Upstream product

• 64404-11-1 phthalyl-DL-valine acid chloride 
• 5115-65-1 N-phthaloyl-DL-valine 
• 516-06-3 D,L-valine 
• 85-44-9 phthalic anhydride 
• 98847-91-7 N-(3-diazo-1-isopropyl-2-oxo-propyl)-phthalimide 
• 67-56-1 methanol 
• 1240283-79-7 C₂₀H₁₉NO₃Se 
• 72212-78-3 (R)-2-(1,3-dioxoisoindolin-2-yl)-3-methylbutanoyl chloride 
• 5115-65-1 (R)-N-phthaloylvaline 
• 640-68-6 D-Val-OH 
• 866395-48-4 (R)-1-diazo-3-phthalimido-4-methylpentan-2-one 
• 186581-53-3 diazomethane 

Downstream Products

• 777904-56-0 4-methyl-3-phthalimido-pentanoic acid 
• 5699-54-7 (R)-3-amino-4-methylpentanoic acid 
• 866395-53-1 N-[1-(2-hydroxy-ethyl)-2-methyl-propyl]-2-hydroxymethyl-benzamide 
• 116173-94-5 (S)-3-Amino-4-methyl-pentan-1-ol 
• 87-41-2 2-benzofuran-1(3H)-one 
• 866395-34-8 (2S,9S,12S,19S)-2,6-cyclo-12,16-cyclo-6,10,16-triaza-19-(benzyloxycarbonylamino)-20-methyl-11-oxo-9-(2'-propyl)heneicosanoic acid methyl ester 
• 866395-31-5 (2S,9S,12S)-2,6-cyclo-12,16-cyclo-6,10,16-triaza-19-(benzyloxycarbonylamino)-11-oxo-9-(2'-propyl)nonadecanoic acid methyl ester 
• 866395-28-0 (2S,9S)-2,6-cyclo-6-aza-9-(benzyloxycarbonylamino)-10-methylundecanoic acid methyl ester 
• 866395-43-9 (S)-1-((S)-3-Benzyloxycarbonylamino-4-methyl-pentyl)-pyrrolidine-2-carboxylic acid 
• 866395-25-7 (S)-1-mesyloxy-N-(benzyloxycarbonyl)-3-amino-4-methylpentane 
• 866395-22-4 (S)-N-(benzyloxycarbonyl)-3-amino-4-methylpentan-1-ol 

Relevant articles and documents

A reasonably stereospecific multistep conversion of Boc-protected α-amino acids to Phth-protected β3-amino acids

A method for the synthesis of β3-amino acids starting from α-amino acids is described. This conversion can be effected by an eight-step procedure which involves the transformation of the carboxylic group into an alkyne followed by a selenium-mediated conversion of the carbon-carbon triple bond to a Se-phenyl selenocarboxylate intermediate. The reactive Se-phenyl selenocarboxylate intermediates can be trapped with water, alcohols or the amine of an amino acid derivative to give β3-amino acids, β3-amino esters or mixed peptides, respectively. The whole transformations of the carboxylic group into an alkyne and of the alkyne group into β3-amino acids may not require purification of the intermediate products but a work-up and isolation procedure of crude materials.