72347-38-7

Basic information

• Product Name: 2H-Pyran, tetrahydro-2-[(1-methylcyclohexyl)oxy]-
• CAS NO: 72347-38-7
• Molecular Formula: C12H22O2
• Molecular Weight: 198.305
• Mol File: 72347-38-7.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2H-Pyran, tetrahydro-2-[(1-methylcyclohexyl)oxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Pyran, tetrahydro-2-[(1-methylcyclohexyl)oxy]-(72347-38-7)
• EPA Substance Registry System: 2H-Pyran, tetrahydro-2-[(1-methylcyclohexyl)oxy]-(72347-38-7)

Safety Data

• Hazardous Substances Data: 72347-38-7(Hazardous Substances Data)

Upstream product

• 72347-37-6 2-((1S,2S)-2-Bromo-1-methyl-cyclohexyloxy)-tetrahydro-pyran 
• 110-87-2 3,4-dihydro-2H-pyran 
• 590-67-0 1-Methylcyclohexanol 

Downstream Products

• 590-67-0 1-Methylcyclohexanol 

Relevant articles and documents

Lithium hexafluorophosphate-catalyzed efficient tetrahydropyranylation of tertiary alcohols under mild reaction conditions

Lithium hexafluorophosphate is found to be an efficient catalyst for the tetrahydropyranylation of tertiary alcohols with dihydropyran under mild reaction conditions.

Bismuth triflate: An efficient catalyst for the formation and deprotection of tetrahydropyranyl ethers

The tetrahydropyranylation of alcohols under solvent-free conditions is efficiently catalyzed by bismuth triflate (0.1 mol %). The experimental procedure is simple and works well with a variety of alcohols and phenols. The catalyst is insensitive to air and small amounts of moisture, easy to handle and relatively nontoxic. The deprotection of THP ethers is also catalyzed by bismuth triflate (1.0 mol %). ( Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003).

A mild and efficient method for tetrahydropyranylation/depyranylation of alcohols and phenols under neutral conditions

Alcohols and phenols are tetrahydropyranylated rapidly in high yields in the presence of lithium bromide and dichloromethane at room temperature. Deprotection of these THP ethers can also be effected readily by mere change of the solvent to methanol and refluxing with excess lithium bromide. Due to neutral reaction conditions employed, the method is also compatible with compounds having acid sensitive functional groups.