7237-81-2 Usage
Originator
Megrin,Yoshitomi,Japan,1972
Manufacturing Process
In 50 ml of pyridine were dissolved 50 grams of nicotinic acid and 50 grams
of p-toluene-sulfonyl chloride. While stirring, the mixture gradually became
hot and colorless, and finally solidified. To the mixture was added dropwise a
solution of 19 grams of 2-hexyl-2-(hydroxymethyl)-1,3-propanediol in 400 ml
of pyridine at a temperature below 80°C. The mixture was heated at 115° to
125°C on an oil bath for 1 hour. After cooling, the mixture was poured into
300 ml of ice water, and extracted with toluene. The toluene layer was washed
in sequence with water, aqueous sodium carbonate and water, dried over
potassium carbonate, and then the toluene was distilled off. The oily residue
was crystallized from ethanol to give 30 grams of 2-hexyl-2-(hydroxymethyl)-
1,3-propanediol trinicotinate, melting at 94° to 96°C. The yield was 59.5%.
Therapeutic Function
Vasodilator
Check Digit Verification of cas no
The CAS Registry Mumber 7237-81-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,2,3 and 7 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 7237-81:
(6*7)+(5*2)+(4*3)+(3*7)+(2*8)+(1*1)=102
102 % 10 = 2
So 7237-81-2 is a valid CAS Registry Number.
InChI:InChI=1/C28H31N3O6/c1-2-3-4-5-12-28(19-35-25(32)22-9-6-13-29-16-22,20-36-26(33)23-10-7-14-30-17-23)21-37-27(34)24-11-8-15-31-18-24/h6-11,13-18H,2-5,12,19-21H2,1H3
