7239-48-7

Basic information

• Product Name: N2-(6-Methyl-1-oxoheptyl-L-A2bu-L-Thr-L-A2bu-)cyclo(L-A2bu*-L-A2bu-D-Leu-L-Leu-L-A2bu-L-A2bu-L-Thr-)
• Synonyms: Colistin B;N2-(6-Methyl-1-oxoheptyl-L-A2bu-L-Thr-L-A2bu-)cyclo(L-A2bu*-L-A2bu-D-Leu-L-Leu-L-A2bu-L-A2bu-L-Thr-);Polymyxin E2
• CAS NO: 7239-48-7
• Molecular Formula: C52H98N16O13
• Molecular Weight: 1155.43392
• Product Categories: Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 7239-48-7.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 646.2 °C at 760 mmHg
• Flash Point: 344.6 °C
• Appearance: /
• Density: 1.759 g/cm³
• Vapor Pressure: 7.07E-16mmHg at 25°C
• Refractive Index: 1.636
• PKA: 13.08±0.70(Predicted)
• CAS DataBase Reference: N2-(6-Methyl-1-oxoheptyl-L-A2bu-L-Thr-L-A2bu-)cyclo(L-A2bu*-L-A2bu-D-Leu-L-Leu-L-A2bu-L-A2bu-L-Thr-)(CAS DataBase Reference)
• NIST Chemistry Reference: N2-(6-Methyl-1-oxoheptyl-L-A2bu-L-Thr-L-A2bu-)cyclo(L-A2bu*-L-A2bu-D-Leu-L-Leu-L-A2bu-L-A2bu-L-Thr-)(7239-48-7)
• EPA Substance Registry System: N2-(6-Methyl-1-oxoheptyl-L-A2bu-L-Thr-L-A2bu-)cyclo(L-A2bu*-L-A2bu-D-Leu-L-Leu-L-A2bu-L-A2bu-L-Thr-)(7239-48-7)

Safety Data

• Hazardous Substances Data: 7239-48-7(Hazardous Substances Data)

Usage

Description

N2-(6-Methyl-1-oxoheptyl-L-A2bu-L-Thr-L-A2bu-)cyclo(L-A2bu-L-A2bu-D-Leu-L-Leu-L-A2bu-L-A2bu-L-Thr-) is a cyclic peptide with a unique structure and composition. It consists of a 6-methyl-1-oxoheptyl group attached to a series of alternating L-A2bu and L-Thr residues, followed by a cyclized ring containing L-A2bu, D-Leu, L-Leu, and L-Thr residues. This complex structure suggests potential applications in various fields.

Uses

Used in Pharmaceutical Industry:
N2-(6-Methyl-1-oxoheptyl-L-A2bu-L-Thr-L-A2bu-)cyclo(L-A2bu-L-A2bu-D-Leu-L-Leu-L-A2bu-L-A2bu-L-Thr-) is used as an antibiotic for the treatment of infectious diseases caused by multi-drug resistant (MDR) gram-negative bacteria. Its unique cyclic structure and composition enable it to target and eliminate these resistant bacteria, providing a promising solution for the growing problem of antibiotic resistance.
Used in Drug Delivery Systems:
N2-(6-Methyl-1-oxoheptyl-L-A2bu-L-Thr-L-A2bu-)cyclo(L-A2bu-L-A2bu-D-Leu-L-Leu-L-A2bu-L-A2bu-L-Thr-) can also be used in drug delivery systems to improve the efficacy and bioavailability of various therapeutic agents. Its cyclic structure and specific residues may allow for targeted delivery to specific cells or tissues, enhancing the therapeutic effects of the drug while minimizing side effects.
Used in Cosmetics Industry:
Due to its unique structure and composition, N2-(6-Methyl-1-oxoheptyl-L-A2bu-L-Thr-L-A2bu-)cyclo(L-A2bu-L-A2bu-D-Leu-L-Leu-L-A2bu-L-A2bu-L-Thr-) may have potential applications in the cosmetics industry. Its ability to form stable complexes with various molecules could be utilized for the development of novel cosmetic products with improved efficacy and safety.
Used in Research and Development:
N2-(6-Methyl-1-oxoheptyl-L-A2bu-L-Thr-L-A2bu-)cyclo(L-A2bu-L-A2bu-D-Leu-L-Leu-L-A2bu-L-A2bu-L-Thr-) can serve as a valuable research tool for studying the structure-function relationships of cyclic peptides and their interactions with various biological targets. This knowledge can be applied to the development of new drugs and therapeutic agents with improved efficacy and selectivity.

InChI:InChI=1/C18H12Br2O6S2/c19-15-5-9-17(10-6-15)27(21,22)25-13-3-1-2-4-14-26-28(23,24)18-11-7-16(20)8-12-18/h5-12H,13-14H2