724-07-2

Basic information

• Product Name: 2,1-Benzisoxazole, 5-chloro-3-(4-chlorophenyl)-
• CAS NO: 724-07-2
• Molecular Formula: C13H7Cl2NO
• Molecular Weight: 264.111
• Mol File: 724-07-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2,1-Benzisoxazole, 5-chloro-3-(4-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,1-Benzisoxazole, 5-chloro-3-(4-chlorophenyl)-(724-07-2)
• EPA Substance Registry System: 2,1-Benzisoxazole, 5-chloro-3-(4-chlorophenyl)-(724-07-2)

Safety Data

• Hazardous Substances Data: 724-07-2(Hazardous Substances Data)

Usage

Class

benzisoxazoles

Molecular structure

a benzene ring fused to an isoxazole ring with chlorine and phenyl substituents

Common uses

in the pharmaceutical industry for the synthesis of biologically active molecules

Potential applications

in drug development for conditions such as cancer, inflammation, and neurological disorders

Value

the compound's specific chemical properties and interactions make it a valuable component in the development of new therapeutic agents.

Upstream product

• 6628-86-0 5-chloro-2-nitrobenzaldehyde 
• 4596-92-3 5-chloro-2,1-benzoisoxazole 
• 106-47-8 4-chloro-aniline 
• 100-00-5 4-chlorobenzonitrile 
• 140-53-4 p-chlorobenzyl cyanide 

Downstream Products

• 7497-53-2 2,6-dichloroacridone 
• 14439-61-3 4-chlorodiazepam 
• 99833-83-7 N-<4-chloro-2-(4-chlorobenzoyl)phenyl>-N-methylphthalimidoacetate 
• 99833-82-6 N-<4-chloro-2-(4-chlorobenzoyl)phenyl>-N-methylchloroacetamide 
• 837-58-1 2-amino-4'-chloro-5-chlorobenzophenone 
• 78961-59-8 5,4'-dichloro-2-methylaminobenzophenone 
• 40539-65-9 5-chloro-3-(4-chloro-phenyl)-benzo[c]isothiazole 

Relevant articles and documents

Metal-Free, Visible-Light-Enabled Direct C3-H Arylation of Anthranils

An eosin Y disodium salt-catalyzed photoredox C-H arylation of anthranils is reported. A variety of aryl diazonium tetrafluoroborates were used as aryl sources, providing the C3 cross-coupled products. The in situ generated reactive radicals were trapped by anthranils, providing an alternative method to transition-metal-catalyzed C-H arylations of anthranils. Gold-catalyzed downstream transformations demonstrate the synthetic potential of these valuable building blocks.

Catalyst-free cyclization of anthranils and cyclic amines: One-step synthesis of rutaecarpine

An efficient synthesis of a variety of quinazolinone derivatives via a direct cyclization reaction between commercially available anthranils and cyclic amines is described. The developed transformation proceeds with the merits of high step- and atom-efficiency, a broad substrate scope, and good to excellent yields, without additional catalysts, and offers a practical way for the preparation of rutaecarpine and its derivatives with structural diversity.