724461-47-6Relevant articles and documents
Enantioselective synthesis of a hindered furyl substituted allyl alcohol intermediate: A case study in asymmetric synthesis
Pihko, Ainoliisa J.,Lundell, Katri,Kanerva, Liisa,Koskinen, Ari M.P.
, p. 1637 - 1643 (2007/10/03)
In the course of the synthesis of the DEFG ring system of cneorin C 1, we were faced with the task of preparing the furyl substituted allyl alcohol 5 enantioselectively. Several different methods starting from enantioselective zinc-mediated alkylations were attempted, but none of them proved entirely satisfactory. The solution turned out to be enzymatic kinetic resolution through a highly enantioselective (E>300) acylation in the presence of Candida antarctica lipase A.