72457-26-2

Basic information

• Product Name: 4-(4-METHOXYPHENYL)BUTAN-1-AMINE
• Synonyms: 4-(4-METHOXYPHENYL)BUTAN-1-AMINE;OTAVA-BB 1038747;4-(4-Methoxyphenyl)butanamine;BenzenebutanaMine, 4-Methoxy-
• CAS NO: 72457-26-2
• Molecular Formula: C₁₁H₁₇NO
• Molecular Weight: 179.26
• Mol File: 72457-26-2.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 293.87°C at 760 mmHg
• Flash Point: 130.371°C
• Appearance: /
• Density: 0.979
• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.516
• PKA: 10.59±0.11(Predicted)
• CAS DataBase Reference: 4-(4-METHOXYPHENYL)BUTAN-1-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-METHOXYPHENYL)BUTAN-1-AMINE(72457-26-2)
• EPA Substance Registry System: 4-(4-METHOXYPHENYL)BUTAN-1-AMINE(72457-26-2)

Safety Data

• Hazardous Substances Data: 72457-26-2(Hazardous Substances Data)

Usage

Description

4-(4-METHOXYPHENYL)BUTAN-1-AMINE is an organic compound with the molecular formula C11H17NO. It is a derivative of butan-1-amine, featuring a 4-methoxyphenyl group attached to the fourth carbon. 4-(4-METHOXYPHENYL)BUTAN-1-AMINE is known for its potential applications in the pharmaceutical industry due to its unique structural properties.

Uses

Used in Pharmaceutical Industry:
4-(4-METHOXYPHENYL)BUTAN-1-AMINE is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with specific therapeutic properties.
Used in Drug Discovery:
4-(4-METHOXYPHENYL)BUTAN-1-AMINE is used as a starting material in the discovery of an orally-active nonsteroidal androgen receptor pure antagonist. 4-(4-METHOXYPHENYL)BUTAN-1-AMINE and its derivatives are being studied to understand the structure-activity relationships, which can lead to the development of more effective drugs for treating various medical conditions.

InChI:InChI=1/C11H17NO/c1-13-11-7-5-10(6-8-11)4-2-3-9-12/h5-8H,2-4,9,12H2,1H3

Upstream product

• 2222-15-3 4-(4-Methoxyphenyl)-butyramide 
• 140-67-0 Estragole 
• 201230-82-2 carbon monoxide 
• 100-46-9 benzylamine 
• 80174-16-9 1-(4’-methoxyphenyl)butan-1,4-diol 
• 24165-60-4 1-(4-methoxyphenyl)but-3-en-1-ol 
• 123-11-5 4-methoxy-benzaldehyde 
• 52999-15-2 4-(p-methoxyphenyl)-3-butyn-1-ol 
• 88537-45-5 4-Methylphenylsulfonic acid 4-(4-methoxyphenyl)butyl ester 
• 587880-56-6 [2-(4-{4-[N'-(3,5-Diamino-6-chloropyrazine-2-carbonyl)guanidino]butyl}phenoxy)ethyl]-carbamic acid tert-butyl ester 
• 22217-80-7 2-(4-methoxyphenyl)-1-pyrroline 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 7643-92-7 4-Amino-1-(4-methoxy-phenyl)-butan-1-one 
• 100-66-3 methoxybenzene 

Downstream Products

• 59181-31-6 N-[4-(4-Methoxy-phenyl)-butyl)-acetamid 
• 853021-75-7 N-[4-(4-methoxyphenyl)but-1-yl]-2-[8-ethoxycarbonyl-2-(3,5-dimethylphenyl)-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl]-2-oxoacetamide 
• 22205-09-0 4-(p-hydroxyphenyl)butylamine 
• 144818-70-2 2,2,2-Trifluoro-N-[4-(4-methoxy-phenyl)-butyl]-acetamide 
• 134304-50-0 Biphenyl-4-carboxylic acid [4-(4-methoxy-phenyl)-butyl]-amide 
• 149080-15-9 [1S-(1α,2α, 3α,4α)]-2-[[3-[4-[[[4-(4-Methoxyphenyl)-butyl]amino]carbonyl]-2-oxazolyl]-7-oxabicyclo-[2.2.1]hept-2-yl]methyl]benzenepropanoic acid, methyl ester 

Relevant articles and documents

Sequential hydroaminomethylation/Pd-catalyzed hydrogenolysis as an atom efficient route to valuable primary and secondary amines

The facile synthesis of valuable primary and secondary amines is reported using a sequential procedure of hydroaminomethylation and Pd-catalyzed hydrogenolysis. The hydroaminomethylation reaction was catalyzed by a cationic Rh(I) iminopyridyl complex and the N-alkylated benzylamines were produced with high chemoselectivity, albeit as mixtures of linear and branched products. Performing the hydrogenolysis reaction using 10% Pd/C, provided access to valuable primary and secondary amines which have applications in the surfactant, pharmaceutical and polymer industries.

Heterocyclization involving benzylic C(sp3)-H functionalization enabled by visible light photoredox catalysis

A general and efficient method for heterocyclization involving benzylic C(sp3)-H functionalization enabled by visible light photoredox catalysis to access a wide range of structurally diverse oxygen as well as nitrogen heterocycles up to a gram scale is reported. The potential application of this new methodology is demonstrated by the total synthesis of (-)-codonopsinine and (+)-centrolobine. Herein it is proposed that selectfluor, unlike a fluorinating reagent, acts as an oxidative quencher and a hydrogen radical acceptor.

COMPOUNDS FOR TREATMENT OF CYSTIC FIBROSIS

Described herein are compounds, compositions, and methods of their use for the treatment of cystic fibrosis.