7250-06-8Relevant articles and documents
CYCLOBUTYL AMIDE MONOACYLGLYCEROL LIPASE MODULATORS
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, (2022/03/31)
Compounds of Formula (I), and pharmaceutically acceptable salts, isotopes, N-oxides, solvates, and stereoisomers thereof, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with MGL modulation, such as those associated with pain, psychiatric disorders, neurological disorders (including, but not limited to depression, major depressive disorder, treatment resistant depression, anxious depression, autism spectrum disorders, Asperger syndrome, and bipolar disorder), cancers and eye conditions: wherein R1, , R3, and L are as defined herein.
Synthesis and Characterization of Bis(xanthate) Complexes of Mo(II) and W(II). Crystal Structure of
Carmona, Ernesto,Contreras, Leopoldo,Sanches, Luis J.,Gutierrez-Puebla, Enrique,Monge, Angeles
, p. 2003 - 2010 (2007/10/02)
The reactions of with potassium xanthates, K(S2COR), give the red crystalline compounds t (4) in which the xanthate groups seem to act as ν3-(S,S',C) pseudo-allylic ligands.Formation of the dicarbonyl species is not detected, but the isopropyl derivative (5) can be obtained by carbonylation of (3) under relatively forcing conditions.The tungsten complex reacts similary with K(S2COR) but gives mixtures of (n=1 or 2).The monophosphine derivatives exhibit n.m.r. spectroscopic features similar to those of (1)--(5), but for the bis(phosphine) species a formulation containing uni- and bi-dentaxe xanthate groups, is proposed, aand this has been confirmed by an X-ray crystal structure determination of complex (9). Formation of the dithiocarbonate complexes, during the reactions leading to the above xanthates has also been observed.Complex (9) istriclinic, space group P1, with unit-cell constants a=8.775(2), b=14.027(5), c=11.806(5) angstroem,α=106.09(2), β=75.74(3), γ=109.06(4)deg, and Z=2.The structure was refined to an R value of 0.032 by using 2878 independent observed refrections.