7251-61-8Relevant articles and documents
Studies on methylglyoxal 1. Fluorometric determination of methylglyoxal using high-performance liquid chromatography
Matsuura,Yoshino,Ooki,et al.
, p. 3567 - 3570 (1985)
A high-performance liquid chromatographic (HPLC) method has been developed for the determination of methylglyoxal (MG). When MG was treated with o-phenylenediamine and trichloroacetic acid, it was converted to a highly fluorescent new compound, 2-(2-benzimidazolyl)-3-methylquinoxaline (BIMQ) the chemical structure of which was elucidated by NMR and MS. BIMQ was analyzed by HPLC using a 4 mm x 25 mm column packed with LiChrosorb Si-60 (10 μ). This method is highly sensitive and was satisfactorily applied to the measurement of MG in biological materials.
Bio-inspired Maillard-Like reactions enable a simple and sensitive assay for colorimetric detection of methylglyoxal
Wang, Shih-Ting,Lin, Yiyang,Spicer, Christopher D.,Stevens, Molly M.
, p. 11026 - 11029 (2015)
A simple and selective assay for detecting methylglyoxal (MGO), a metabolite associated with diabetes, was developed by combining a bio-inspired chemical reaction with the anti-aggregation of gold nanoparticles. This assay could detect MGO at as low as 1 μM by the naked eye and 0.05 μM by UV/vis spectrometry, within the clinical range marking oxidative stress in diabetes, and demonstrated high selectivity over other physiologically relevant ketones and aldehydes.
Hydrogen Auto-transfer Synthesis of Quinoxalines from o-Nitroanilines and Biomass-based Diols Catalyzed by MOF-derived N,P Co-doped Cobalt Catalysts
Sun, Kangkang,Li, Dandan,Lu, Guo-Ping,Cai, Chun
, p. 373 - 381 (2020/12/09)
A Co-based heterogeneous catalyst supported on N,P co-doped porous carbon (Co@NCP) is prepared via a facile in-situ doping-carbonization method. The Co@NCP composite features a large surface area, high pore volume, high-density and strong basic sites. Furthermore, doping of P atoms can regulate the electronic density of Co. Therefore, Co@NCP exhibits good performance for the synthesis of quinoxalines from o-nitroanilines and biomass-derived diols under alkali-free conditions.
Method for synthesizing quinoxaline compound under visible light induced iron catalysis condition
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Paragraph 0035-0041; 0287-0308, (2021/07/10)
The invention belongs to the technical field of compound synthesis, and particularly relates to a method for synthesizing quinoxaline compounds under visible light induced iron catalysis conditions. The method comprises the following steps: by taking non-activated aliphatic amine and o-phenylenediamine as raw materials, under the action of a photosensitizer, under the illumination of visible light, reacting in a solvent at room temperature and under oxygen conditions to generate the quinoxaline compound. The method has better substrate universality and relatively mild reaction conditions, not only realizes synthesis of the quinoxaline compound for the first time, but also widens the field of organic synthesis.