7251-82-3

Basic information

• Product Name: 4-methylisoindole-1,3-dione
• Synonyms: 4-methylisoindole-1,3-dione;4-Methyl-1H-Isoindole-1,3(2H)-dione;4-methylisoindoline-1,3-dione
• CAS NO: 7251-82-3
• Molecular Formula: C₉H₇NO₂
• Molecular Weight: 161.15738
• Mol File: 7251-82-3.mol
• Article Data: 6

Chemical Properties

• Melting Point: 183-189℃
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.301g/cm³
• Refractive Index: 1.598
• CAS DataBase Reference: 4-methylisoindole-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methylisoindole-1,3-dione(7251-82-3)
• EPA Substance Registry System: 4-methylisoindole-1,3-dione(7251-82-3)

Safety Data

• Hazardous Substances Data: 7251-82-3(Hazardous Substances Data)

Usage

Description

4-methylisoindole-1,3-dione, also known as 4-methyl-1H-isoindole-1,3(2H)-dione, is a chemical compound that appears as a yellowish-brown powder. It has a molecular formula of C9H7NO2 and a molecular weight of 161.16 g/mol. 4-methylisoindole-1,3-dione serves as a crucial building block in the synthesis of various valuable molecules, including pharmaceuticals, agrochemicals, dyes, and pigments.

Uses

Used in Pharmaceutical Industry:
4-methylisoindole-1,3-dione is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 4-methylisoindole-1,3-dione is utilized as an intermediate for the production of agrochemicals. This contributes to the development of effective pesticides and other agricultural products.
Used in Dye and Pigment Production:
4-methylisoindole-1,3-dione is employed as an intermediate in the manufacturing process of dyes and pigments. Its chemical properties make it suitable for creating a wide range of colorants used in various industries.
Used in Organic Compound Synthesis:
4-methylisoindole-1,3-dione is also used in the synthesis of other organic compounds, highlighting its versatility and importance in the chemical industry. Its role as a building block facilitates the creation of diverse molecules for various applications.

InChI:InChI=1/C9H7NO2/c1-5-3-2-4-6-7(5)9(12)10-8(6)11/h2-4H,1H3,(H,10,11,12)

Upstream product

• 136918-14-4 phthalimide 
• 50-00-0 formaldehyd 
• 36715-97-6 3-methylphthalonitrile 
• 37102-74-2 3-methylphthalic acid 
• 1147550-11-5 ammonium thiocyanate 
• 14346-57-7 3-methyl-phthalic acid-1-methyl ester 
• 127510-98-9 methyl 2-cyano-6-methylbenzoate 
• 4792-30-7 3-methylphthalic acid anhydride 
• 63089-46-3 3-methylphthalamide 
• 55321-98-7 2,6-dimethylbenzamide 
• 7664-93-9 sulfuric acid 
• 7732-18-5 water 
• 526-73-8 1,2,3-trimethylbenzene 
• 130403-08-6 D₂₉₁₆ 

Downstream Products

• 63089-46-3 3-methylphthalamide 
• 739365-30-1 4-methyl-2,3-dihydro-1H-isoindole 
• 83844-42-2 2,3-Dihydro-2,4-dimethyl-1H-isoindole-1,3-dione 

Relevant articles and documents

Synthesis method of phthalimide and phenyl ring-substituted phthalimide derivative

The invention provides a synthesis method of phthalimide and a phenyl ring-substituted phthalimide derivative. The synthesis method comprises that aromatic ketone and ammonia gas or an ammonia gas precursor as substrates and air or oxygen as an oxygen source undergo a reaction under catalyst action and liquid phase conditions to produce phthalimide and a phenyl ring-substituted phthalimide derivative. The synthesis method is mild, realizes high oxidation efficiency and a high product yield, utilizes oxygen or air as an oxygen source, is economic and eco-friendly and has a good application prospect.

Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 2: Isoindoline containing inhibitors

To obtain selective and potent inhibitors of dipeptidyl peptidases 8 and 9, we synthesized a series of substituted isoindolines as modified analogs of allo-Ile-isoindoline, the reference DPP8/9 inhibitor. The influence of phenyl substituents and different P2 residues on the inhibitors' affinity toward other DPPs and more specifically, their potential to discriminate between DPP8 and DPP9 will be discussed. Within this series compound 8j was shown to be a potent and selective inhibitor of DPP8/9 with low activity toward DPP II.

Chemical oxidation of an anticonvulsant N-(5'-methylisoxazol-3-yl) 2,6- dimethylbenzamide (D2916)

The new anticonvulsant N-(5'-methylisoxazol-3-yl)-2,6-dimethylbeazamide (D2916), which presents two kinds of methyl groups which could be oxidized, was submitted to various chemical oxidizing agents. Several sites and degrees of oxidation were observed. The main oxidized site was the arylmethyl group without cleavage of the isoxazole ring, leading via carboxylic acid and primary alcohol intermediates to phthalimide and lactame derivatives. In no case was the methyl group of the isoxazole moiety hydroxylated.