7253-65-8

Basic information

• Product Name: N-[(4-methylphenyl)methylideneamino]benzamide
• CAS NO: 7253-65-8
• Molecular Formula: C₁₅H₁₄N₂O
• Molecular Weight: 238.289
• Mol File: 7253-65-8.mol
• Article Data: 22

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Density: 1.06g/cm³
• CAS DataBase Reference: N-[(4-methylphenyl)methylideneamino]benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(4-methylphenyl)methylideneamino]benzamide(7253-65-8)
• EPA Substance Registry System: N-[(4-methylphenyl)methylideneamino]benzamide(7253-65-8)

Safety Data

• Hazardous Substances Data: 7253-65-8(Hazardous Substances Data)

Upstream product

• 104-87-0 4-methyl-benzaldehyde 
• 613-94-5 benzoic acid hydrazide 
• 65-85-0 benzoic acid 
• 93-89-0 benzoic acid ethyl ester 

Downstream Products

• 77420-66-7 N-[1-Phenyl-1-thiocyanato-meth-(Z)-ylidene]-N'-[1-p-tolyl-meth-(E)-ylidene]-hydrazine 
• 1192113-31-7 (R)-N'-(1-p-tolylbut-3-enyl)benzohydrazide 
• 1192113-59-9 (1R,2R)-N'-(2-methyl-1-p-tolylbut-3-enyl)benzohydrazide 
• 1448781-77-8 ((3S,3aS,6aS)-3-p-tolyl-2,3,3a,4-tetrahydrocyclopenta[c]pyrazol-1(6aH)-yl)(phenyl)methanone 
• 1366284-24-3 N-(2,2-difluoro-3-oxo-3-phenyl-1-p-tolylpropyl)benzohydrazide 
• 1185855-47-3 (+/-)-2-(4-methylphenyl)-3-acetyl-5-phenyl-2,3-dihydro-1,3,4-oxadiazole 
• 1328893-00-0 (2R)-(+)-2-(4-methylphenyl)-3-acetyl-5-phenyl-2,3-dihydro-1,3,4-oxadiazole 
• 1328893-01-1 (2S)-(-)-2-(4-methylphenyl)-3-acetyl-5-phenyl-2,3-dihydro-1,3,4-oxadiazole 
• 1259388-06-1 N'-(2,2-difluoro-3-oxo-3-phenyl-1-(p-tolyl)propyl)benzohydrazide 
• 1263414-96-5 [CoCl₂(4-methylbenzaldehyde benzoylhydrazone-1H)] 

Relevant articles and documents

Oxadiazole based Os(IV) compounds as potential DNA intercalator and cytotoxic agents

Os(IV) compounds and ligands have been synthesized and well characterized. DNA cleavage tendency of compounds has been evaluated using gel electrophoresis and binding behavior has been evaluated by viscosity measurements, absorption titration, fluorescenc

Synthesis and Fluorescence Properties of Eu3+, Tb3+ Complexes with Schiff Base Derivatives

Novel Schiff base ligands derived from N′-benzylidene-benzohydrazide (substituted by-H,-CH3,-OCH3,-Cl) and 2-chloro-N-phenylacetamide were synthesized. The solid complexes of rare earth (Eu, Tb) nitrate with these Schiff base ligands

N-(1'-naphthyl)-3,4,5-trimethoxybenzohydrazide as microtubule destabilizer: Synthesis, cytotoxicity, inhibition of cell migration and in vivo activity against acute lymphoblastic leukemia

Tubulin-interacting agents, like vinca alkaloid and taxanes, play a fundamental role in cancer chemotherapy, making cellular microtubules (MT), one of the few validated anticancer targets. Cancer resistance to classical MT inhibitors has motivated the development of novel molecules with increased efficacy and lower toxicity. Aiming at designing structurally-simple inhibitors of MT assembly, we synthesized a series of thirty-one 3,4,5-trimethoxy-hydrazones and twenty-five derivatives or analogs. Docking simulations suggested that a representative N-acylhydrazone could adopt an appropriate stereochemistry inside the colchicine-binding domain of tubulin. Several of these compounds showed anti-leukemia effects in the nanomolar concentration range. Interference with MT polymerization was validated by the compounds' ability to inhibit MT assembly at the biochemical and cellular level. Selective toxicity investigations done with the most potent compound, a 3,4,5-trimethoxy-hydrazone with a 1-naphthyl group, showed remarkably selective toxicity against leukemia cells in comparison with stimulated normal lymphocytes, and no acute toxicity in vivo. Finally, this molecule was as active as vincristine in a murine model of human acute lymphoblastic leukemia at a weekly dose of 1 mg/kg.