7254-29-7

Basic information

• Product Name: 2-amino-5-nitropyrimidin-4(3H)-one
• Synonyms: 2-amino-5-nitropyrimidin-4(3H)-one;2-AMino-5-nitropyriMidin-4(1H)-one
• CAS NO: 7254-29-7
• Molecular Formula: C₄H₄N₄O₃
• Molecular Weight: 156
• Mol File: 7254-29-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 417.2°C at 760 mmHg
• Flash Point: 206.1°C
• Appearance: /
• Density: 2.02g/cm³
• Vapor Pressure: 1.49E-07mmHg at 25°C
• Refractive Index: 1.798
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 2-amino-5-nitropyrimidin-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-5-nitropyrimidin-4(3H)-one(7254-29-7)
• EPA Substance Registry System: 2-amino-5-nitropyrimidin-4(3H)-one(7254-29-7)

Safety Data

• Hazardous Substances Data: 7254-29-7(Hazardous Substances Data)

Usage

Description

2-amino-5-nitropyrimidin-4(3H)-one, also known as 4-amino-3-nitropyrimidin-5(2H)-one, is a chemical compound with the molecular formula C4H3N4O3. It is a yellow crystalline solid that serves as an intermediate in the synthesis of pharmaceuticals and agrochemicals. With a molecular weight of 141.09 g/mol, this compound requires careful handling due to its potential harmful effects if ingested, inhaled, or if it comes into contact with the skin or eyes. It should be stored in a cool, dry, and well-ventilated area away from sources of ignition and incompatible materials.

Uses

Used in Pharmaceutical Industry:
2-amino-5-nitropyrimidin-4(3H)-one is used as a chemical intermediate for the synthesis of various pharmaceuticals. It plays a crucial role in the development of new drugs, contributing to the advancement of medical treatments and therapies.
Used in Agrochemical Industry:
In the agrochemical sector, 2-amino-5-nitropyrimidin-4(3H)-one is utilized as an intermediate in the production of agrochemicals. It aids in the creation of substances that help protect crops and enhance agricultural productivity, thereby supporting food security and sustainable agriculture practices.

InChI:InChI=1/C4H4N4O3/c5-4-6-1-2(8(10)11)3(9)7-4/h1H,(H3,5,6,7,9)

Upstream product

• 99968-75-9 2-ethoxy-5-nitro-3H-pyrimidin-4-one 
• 108-53-2 isocytosine 

Downstream Products

• 611-08-5 5-nitrobarbituric acid 
• 77994-12-8 2,5-diaminopyrimidin-4(3H)-one 
• 3005-72-9 C₆H₆N₄O₄ 
• 160948-35-6 2-amino-4-chloro-5-nitropyrimidine 

Relevant articles and documents

6,5-HETEROCYCLIC PROPARGYLIC ALCOHOL COMPOUNDS AND USES THEREFOR

The invention relates to novel compounds of Formula I: wherein A, Y, R1, R2 and the subscript b each has the meaning as described herein and compounds of Formula I, and stereoisomers, geometric isomers, tautomers, solvates, metabolites, isotopes, pharmaceutically acceptable salts, or prodrugs thereof. Compounds of Formula I and pharmaceutical compositions thereof are useful in the treatment of disease and disorders in which undesired or over-activation of NF-kB signaling is observed.

Mapping the landscape of potentially primordial informational oligomers: Oligodipeptides tagged with 2,4-disubstituted 5-aminopyrimidines as recognition elements

(Chemical Equation Presented) Bit different: 2,4-Dioxo- and 2,4-diamino-5-aminopyrimidine nuclei attached to an oligodipeptide backbone display a disparity in their base-pairing strength which is opposite to that shown by corresponding triazines. This behavior points to a remarkable correlation between pairing strength and ΔpKa values of pairs of complementary bases.