72581-71-6 Usage
Description
Isosilybin is a flavanolignan found in the extract of S. marianum fruits with antioxidant and anticancer activities. It inhibits lipid peroxidation in rat liver microsomes (IC50 = 32 μM) and reduces ADP/Fe3+-induced malondialdehyde (MDA) production and lactate dehydrogenase (LDH) release in rat hepatocytes. Isosilybin inhibits the production of reactive oxygen species (ROS), MDA and LDH release, and reduction in total antioxidant capacity induced by amyloid-β (25-35) (Aβ25-35) in HT-22 hippocampal cells. It also increases protein and mRNA expression of heme oxygenase-1 (HO-1), glutathione S-transferase (GST), and the aldo-keto reductases (AKCR) 1C1 and AKCR1C2 in HT-22 cells. In vivo, isosilybin (50 and 100 mg/kg) reduces tumor volume and increases tumor cell apoptosis in a DU145 prostate cancer mouse xenograft model. It also reduces expression of the tumor angiogenesis markers CD31, nestin, VEGF, VEGFR1, VEGFR2, phospho-Akt, and HIF-1α in tumor tissue without reducing blood vessel count in non-cancerous liver, lung, and kidney tissue in DU145 tumor-bearing mice.
Uses
Different sources of media describe the Uses of 72581-71-6 differently. You can refer to the following data:
1. Useful in the treatment of liver disease.
2. Isosilybin is useful in the treatment of liver disease
Definition
ChEBI: A flavonolignan isolated from Silybum marianum.
Check Digit Verification of cas no
The CAS Registry Mumber 72581-71-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,2,5,8 and 1 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 72581-71:
(7*7)+(6*2)+(5*5)+(4*8)+(3*1)+(2*7)+(1*1)=136
136 % 10 = 6
So 72581-71-6 is a valid CAS Registry Number.
InChI:InChI=1/C25H22O10/c1-32-17-6-11(2-4-14(17)28)24-20(10-26)33-18-7-12(3-5-16(18)34-24)25-23(31)22(30)21-15(29)8-13(27)9-19(21)35-25/h2-9,20,23-29,31H,10H2,1H3/t20?,23-,24?,25+/m0/s1
72581-71-6Relevant articles and documents
Benzodioxans by Oxidative Phenol Coupling. Synthesis of Silybin
Merlini, Lucio,Zanarotti, Antonio,Pelter, Andrew,Rochefort, Malcolm P.,Haensel, Rudolf
, p. 775 - 778 (2007/10/02)
Oxidative coupling of substituted catechols with isoeugenol or coniferyl alcohol in the presence of silver oxide affords 2,3-trans-1,4-benzodioxans in good yield.The reaction is highly regioselective when the catechol bears an alkyl substituent, much less
