72617-60-8 Usage
General Description
7,12-dimethylbenz(a)anthracene-3,4-dihydrodiol, also known as DMBA-3,4-dihydrodiol, is a metabolite of the carcinogenic polycyclic aromatic hydrocarbon 7,12-dimethylbenz(a)anthracene (DMBA). It is formed through the action of cytochrome P450 enzymes in the liver, and is a potent genotoxic and mutagenic compound. DMBA-3,4-dihydrodiol has been found to induce DNA damage and promote the development of tumors in various experimental models. It is known to form covalent adducts with DNA, leading to mutations and potentially contributing to the development of cancer. This chemical is of significant interest in the field of toxicology and cancer research due to its role in the molecular mechanisms of carcinogenesis and its potential as a target for cancer prevention and treatment strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 72617-60-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,2,6,1 and 7 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 72617-60:
(7*7)+(6*2)+(5*6)+(4*1)+(3*7)+(2*6)+(1*0)=128
128 % 10 = 8
So 72617-60-8 is a valid CAS Registry Number.
InChI:InChI=1/C20H18O2/c1-11-13-5-3-4-6-14(13)12(2)19-15(11)7-8-17-16(19)9-10-18(21)20(17)22/h3-10,18,20-22H,1-2H3
72617-60-8Relevant articles and documents
Synthesis of the o-Quinones and Other Oxidized Metabolites of Polycyclic Aromatic Hydrocarbons Implicated in Carcinogenesis
Harvey, Ronald G.,Dai, Qing,Ran, Chongzhao,Penning, Trevor M.
, p. 2024 - 2032 (2007/10/03)
Efficient new syntheses of the o-quinone derivatives of benzo[a]pyrene (BPQ), 7,12-dimethylbenz-[a] anthracene (DMBAQ), and benz[a]anthracene (BAQ), implicated as active carcinogenic metabolites of the parent polycyclic aromatic hydrocarbons (PAHs), are reported. These PAH quinones also serve as starting compounds for the synthesis of the other active metabolites of these PAHs thought to be involved in their mechanism(s) of carcinogenesis. The latter include the corresponding o-catechols, trans-dihydrodiols, and the corresponding anti- and syn-diol epoxides.
Synthesis of the active diol epoxide metabolites of the potent carcinogenic hydrocarbon 7,12-dimethylbenz[a]anthrene
Lee,Harvey
, p. 3502 - 3507 (2007/10/02)
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