72652-34-7

Basic information

• Product Name: 1-(4-ACETYL-1H-PYRROL-2-YL)-2,2,2-TRICHLORO-1-ETHANONE
• Synonyms: 1-(4-ACETYL-1H-PYRROL-2-YL)-2,2,2-TRICHLORO-1-ETHANONE;1-(4-ACETYL-1H-PYRROL-2-YL)-2,2,2-TRICHLOROETHANONE;1-(4-ACETYL-1H-PYRROL-2-YL)-2,2,2-TRICHLOROETHAN-1-ONE
• CAS NO: 72652-34-7
• Molecular Formula: C₈H₆Cl₃NO₂
• Molecular Weight: 254.5
• Mol File: 72652-34-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 201-203°C
• Boiling Point: 383.1°C at 760 mmHg
• Flash Point: 185.5°C
• Appearance: /
• Density: 1.542g/cm³
• Vapor Pressure: 4.49E-06mmHg at 25°C
• Refractive Index: 1.584
• PKA: 12.56±0.50(Predicted)
• CAS DataBase Reference: 1-(4-ACETYL-1H-PYRROL-2-YL)-2,2,2-TRICHLORO-1-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-ACETYL-1H-PYRROL-2-YL)-2,2,2-TRICHLORO-1-ETHANONE(72652-34-7)
• EPA Substance Registry System: 1-(4-ACETYL-1H-PYRROL-2-YL)-2,2,2-TRICHLORO-1-ETHANONE(72652-34-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 72652-34-7(Hazardous Substances Data)

Usage

General Description

1-(4-ACETYL-1H-PYRROL-2-YL)-2,2,2-TRICHLORO-1-ETHANONE is a chemical compound with the molecular formula C8H7Cl3NO. It is an organic compound that contains a pyrrole ring with an acetyl group attached to it, and a trichloroethanone group. 1-(4-ACETYL-1H-PYRROL-2-YL)-2,2,2-TRICHLORO-1-ETHANONE is often used in the pharmaceutical industry as an intermediate for the synthesis of various pharmaceutical drugs. It may also have applications in research and development for the creation of new compounds. The trichloroethanone group makes this compound highly reactive and potentially useful in various chemical reactions. Overall, 1-(4-ACETYL-1H-PYRROL-2-YL)-2,2,2-TRICHLORO-1-ETHANONE is a versatile chemical with potential applications in pharmaceuticals and chemical research.

InChI:InChI=1/C8H6Cl3NO2/c1-4(13)5-2-6(12-3-5)7(14)8(9,10)11/h2-3,12H,1H3

Upstream product

• 35302-72-8 pyrrol-2-yl trichloromethyl ketone 
• 75-36-5 acetyl chloride 

Downstream Products

• 1429500-85-5 tert-butyl 4-[2-(2,4-dimethoxybenzyl)-7-iodo-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]piperidine-1 carboxylate 
• 1429500-83-3 tert-butyl 4-(2-{(2,4-dimethoxybenzyl)[(4-iodo-1H-pyrrol-2-yl)carbonyl]amino}-1-hydroxyethyl)piperidine-1-carboxylate 
• 1269823-38-2 (4-(1-(1-cyano-3-cyclohexylpropan-2-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-c]pyridazin-7-yl)methyl pivalate 
• 1269823-37-1 3-(4-(7H-pyrrolo[2,3-c]pyridazin-4-yl)-1H-pyrazol-1-yl)-4-cyclohexylbutane nitrile 
• 1269823-33-7 4-phenyl-7H-pyrrolo[2,3-c]pyridazine 
• 1269823-24-6 (4-(1-(2-cyano-1-cyclohexylethyl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-c]pyridazin-7-yl)methyl pivalate 
• 1269823-23-5 3-(4-(7H-pyrrolo[2,3-c]pyridazin-4-yl)-1H-pyrazol-1-yl)-3-cyclohexylpropane nitrile 
• 1269822-91-4 4-(1-(1-ethoxyethyl)-1H-pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-c]pyridazine 
• 1269823-02-0 4-chloro-7H-pyrrolo[2, 3-c]pyridazine 
• 1269822-95-8 methyl 4-hydroxy-7H-pyrrolo[2,3-c]pyridazine-6-carboxylate 
• 1269823-82-6 (R)-(4-(1-(1-(3-hydroxyphenyl)-3-oxopropyl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-c]pyridazin-7-yl)methyl pivalate 
• 1269824-46-5 methyl 4-acetyl-5-amino-1H-pyrrole-2-carboxylate 
• 1269823-81-5 (R)-(4-(1-(2-cyano-1-(3-hydroxyphenyl)ethyl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-c]pyridazin-7-yl)methyl pivalate 
• 1269823-80-4 (R)-3-(4-(7H-pyrrolo[2,3-c]pyridazin-4-yl)-1H-pyrazol-1-yl)-3-(3-hydroxyphenyl)propanenitrile 

Relevant articles and documents

Synthesis of 4,4-dimethyl-2-(2-pyrrolyl)-2-oxazolines

– A practical synthesis of 4,4-dimethyl-2-oxazolines on pyrrole was achieved via the cyclization of the corresponding amides, which were derived from the trichloroacetylpyrroles. The established conditions were applicable to pyrroles bearing a ketone or an ester moiety. In addition to pyrroles, the method could be extended to the synthesis of the indole derivative.

The intramolecular photometathesis of pyrroles

UV irradiation of various electron deficient pyrrole derivatives induces a novel methathesis sequence resulting in selective cleavage of the 2,3-pyrrole bond. The overall sequence has been shown to proceed by two discrete wavelength-dependent steps involving sequential [2+2] cyclobutane formation followed by photochemically mediated retro-[2+2] to the products. Copyright

Synthesis of 2-Alkylputrescines from 3-Alkylpyrroles

Acylation of 2-(trichloroacetyl)pyrrole gave the 4-acyl derivatives (from 4-formyl to 4-hexanoyl) in good yields.Alkaline treatment gave corresponding 4-acyl-2-pyrrolecarboxylic acids, were decarboxylated to the 3-acylpyrroles by prior conversion to the 3-acyl-2,4,5-triiodopyrroles followed by hydrogenolysis.The 3-acylpyrroles were reduced by treatment with hydrazine in alkaline medium to the 3-alkylpyrroles.The latter were ring-opened by treatment with hydroxylamine in the presence of bicarbonate to give the dioximes of the corresponding 2-alkylsuccinaldehydes, which were then reduced to the 2-alkylpurescines (1,4-diaminobutanes).Ring-opening of 2,3-dimethylpyrrole followed by reduction of the dioxime gave 1,2-dimethylputrescine; the same sequence gave 1,3-dimethylputrescine from 2,4-dimethylpyrrole, while 3,4-dimethylpyrrole did not ring-open and gave the dioxime of 3,4-dimethylmaleimide.