7271-44-5

Basic information

• Product Name: 3-METHYL-1,2,4-TRIAZOLE-5-THIONE
• Synonyms: 3-Mercapto-5-methyl-1,2,4-triazole;4-triazole-3-thione,1,2-dihydro-5-methyl-3h-2;5-Methyl-1,2,4-triazole-3-thione;5-methyl-2,4-dihydro-3h-1,2,4-triazole-3-thione;3-METHYL-1,2,4-TRIAZOLE-5-THIONE;3-METHYL-1H-1,2,4-TRIAZOL-5-YLHYDROSULFIDE;3-METHYL-1H-1,2,4-TRIAZOLE-5-THIOL;3H-1,2,4-Triazole-3-thione, 1,2-dihydro-5-methyl-
• CAS NO: 7271-44-5
• Molecular Formula: C₃H₅N₃S
• Molecular Weight: 115.16
• Mol File: 7271-44-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 144.2 °C at 760 mmHg
• Flash Point: 41 °C
• Appearance: /
• Density: 1.56 g/cm³
• Vapor Pressure: 5.15mmHg at 25°C
• Refractive Index: 1.752
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-METHYL-1,2,4-TRIAZOLE-5-THIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHYL-1,2,4-TRIAZOLE-5-THIONE(7271-44-5)
• EPA Substance Registry System: 3-METHYL-1,2,4-TRIAZOLE-5-THIONE(7271-44-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 7271-44-5(Hazardous Substances Data)

Usage

Description

3-METHYL-1,2,4-TRIAZOLE-5-THIONE is an organic compound with the chemical formula C2H3N3S. It is a heterocyclic compound that features a triazole ring fused with a thioketone group. This unique structure endows it with specific chemical properties and potential applications in various fields.

Uses

Used in Analytical Chemistry:
3-METHYL-1,2,4-TRIAZOLE-5-THIONE is used as a suitable ionophore for the fabrication of a new gadolinium(III) ion selective potentiometric sensor. Its ability to selectively interact with specific metal ions makes it a valuable component in the development of sensors for detecting and measuring the concentration of gadolinium ions in various samples.
Used in Pharmaceutical Industry:
3-METHYL-1,2,4-TRIAZOLE-5-THIONE is also used as a potential metallo-β-lactamase inhibitor. Metallo-β-lactamases are enzymes that confer resistance to β-lactam antibiotics, a major class of antibiotics used to treat bacterial infections. By inhibiting these enzymes, 3-METHYL-1,2,4-TRIAZOLE-5-THIONE can help restore the effectiveness of β-lactam antibiotics and combat antibiotic resistance.

InChI:InChI=1/C3H5N3S/c1-2-4-3(7)6-5-2/h1H3,(H2,4,5,6,7)

Upstream product

• 25835-31-8 1-(1-ethoxy-ethylidene)-thiosemicarbazide 
• 32894-07-8 S-benzyl thioacetimidate hydrochloride 
• 79-19-6 thiosemicarbazide 
• 26934-29-2 2,3-dimethylthiazolinium iodide 
• 70489-82-6 2,3,4,4-tetramethyloxazolin-3-ium iodide 
• 25835-31-8 C₅H₁₁N₃OS 

Downstream Products

• 64679-65-8 (5-methyl-1H-[1,2,4]triazol-3-ylsulfanyl)-acetic acid 
• 7170-01-6 3-methyl-1H-[1,2,4]triazole 
• 85093-41-0 3-Vinylthio-5-methyl-1,2,4-triazole 
• 111014-65-4 1-Chloro-3-(5-phenyl-4H-[1,2,4]triazol-3-ylsulfanyl)-propan-2-ol 
• 162661-07-6 2-methyl-6-(4-methylbenzylidene)thiazolo<3,2-b>-1,2,4-triazol-5(6H)-one 
• 34985-98-3 5-methyl-3-methylthio-1H-1,2,4-triazole 
• 1333343-02-4 6-amino-2-methylthiazolo[3,2-b][1,2,4]triazole-5-carbonitrile 
• 1393829-27-0 C₁₀H₁₁N₃S₂ 
• 1393829-26-9 C₉H₈FN₃S₂ 
• 1393829-25-8 C₉H₈BrN₃S₂ 

Relevant articles and documents

CARBON TRANSFER REACTIONS OF Δ2-OXAZOLINIUM AND THIAZOLINIUM CATIONS

Δ2-Oxazolinium and thiazolinium cations with or without an appendage at any of the heteroatoms transfer their C(2) units at the carboxylic acid oxidation level to binucleophiles and provide the corresponding heterocycles, thus mimicking carbon transfer reactions exhibited by THF models, N-methyl N'-tosyl/acetyl imidazolinium cations.However, these azolinium cations react with phenethylamine and tryptamine to furnish their N-acyl derivatives.

Δ2-OXAZOLINIUM AND THIAZOLINIUM CATIONS AS ONE CARBON UNIT TRANSFER AGENTS

N-Methyl-Δ2-oxazolinium and thiazolinium cations tranfer their C2 units to binucleophiles in refluxing DMF or CH3CN and provide the corresponding heterocycles.