7272-54-0

Basic information

• Product Name: 3-(2-AMino-ethyl)-1H-indole-5-carboxylic acid ethyl ester
• Synonyms: 3-(2-AMino-ethyl)-1H-indole-5-carboxylic acid ethyl ester
• CAS NO: 7272-54-0
• Molecular Formula: C₁₃H₁₆N₂O₂
• Molecular Weight: 232.27834
• Mol File: 7272-54-0.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(2-AMino-ethyl)-1H-indole-5-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-AMino-ethyl)-1H-indole-5-carboxylic acid ethyl ester(7272-54-0)
• EPA Substance Registry System: 3-(2-AMino-ethyl)-1H-indole-5-carboxylic acid ethyl ester(7272-54-0)

Safety Data

• Hazardous Substances Data: 7272-54-0(Hazardous Substances Data)

Usage

Description

3-(2-Amino-ethyl)-1H-indole-5-carboxylic acid ethyl ester is a chemical compound with the molecular formula C14H16N2O2. It is a derivative of indole, a heterocyclic aromatic organic compound.
Used in Pharmaceutical Research:
3-(2-Amino-ethyl)-1H-indole-5-carboxylic acid ethyl ester is used as a starting material for the synthesis of various biologically active molecules and pharmaceutical products. It has potential applications in the development of new drugs for the treatment of various diseases and medical conditions.
Used in Organic Synthesis:
3-(2-Amino-ethyl)-1H-indole-5-carboxylic acid ethyl ester is used as a building block for the synthesis of other complex organic compounds.

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Relevant articles and documents

SEPIAPTERIN REDUCTASE INHIBITORS FOR THE TREATMENT OF PAIN

Disclosed herein are small molecule heterocyclic inhibitors of sepiapterin reductase (SPR), and pro-drugs and pharmaceutically acceptable salts thereof. The Also featured are pharmaceutical compositions of the compounds and uses of these compounds for the treatment or prevention of pain (e.g., inflammatory pain, nociceptive pain, functional pain, and neuropathic pain)

Synthesis and Serotonergic Activity of 5-(Oxadiazolyl)tryptamines: Potent Agonists for 5-HT1D Receptors

The synthesis and 5-HT1D receptor activity of a novel series of 5-(oxadiazolyl)tryptamines is described.Modifications of the oxadiazole 3-substituent, length of the linking chain (n), and the amine substituents are explored and reveal a large binding pocket in the 5-HT1D receptor domain.Oxadiazole substituents such as benzyl are accommodated without loss of agonist potency or efficacy.The incorporation of polar functionality on a phenyl or benzyl spacer group results in a 10-fold increase in affinity and functional potency.Optimal 5-HT1D activity is observed when the heterocycle is conjugated with the indole and the benzyl sulfonamides 20t and 20u represent some of the most potent 5-HT1D agonist known.Replacement of O for S in the heterocycle leads to a further increase in potency.Deletion of oxadiazole N-2 does not reduce activity, suggesting the requirements for only one H-bond acceptor in this location.The selectivity of these compounds for 5-HT1D receptors over other serotonergic receptors is discussed.Sulfonamide 20t shows 1000-fold selectivity for 5-HT1D over 5-HT2, 5-HT1C, and 5-HT3 receptors and 10-fold selectivity with respect to 5-HT1A receptors.The functional activity of this series of compounds is studied and demonstrates high 5-HT1D receptor potency and efficacy comparable to that of 5-HT.