72734-74-8

Basic information

• Product Name: Oxirane, [4-(phenylmethoxy)phenyl]-
• CAS NO: 72734-74-8
• Molecular Formula: C15H14O2
• Molecular Weight: 226.275
• Mol File: 72734-74-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Oxirane, [4-(phenylmethoxy)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Oxirane, [4-(phenylmethoxy)phenyl]-(72734-74-8)
• EPA Substance Registry System: Oxirane, [4-(phenylmethoxy)phenyl]-(72734-74-8)

Safety Data

• Hazardous Substances Data: 72734-74-8(Hazardous Substances Data)

Upstream product

• 131965-52-1 (S)-(+)-2-bromo-1-(4-benzyloxyphenyl)ethanol 
• 108-95-2 phenol 
• 6305-04-0 p-hydroxyphenacyl chloride 
• 63365-56-0 1-(4-(benzyloxy)phenyl)-2-chloroethanone 
• 100-39-0 benzyl bromide 
• 36438-64-9 p-benzyloxystyrene 
• 4397-53-9 p-benzyloxybenzaldehyde 
• 1774-47-6 trimethylsulfoxonium iodide 

Downstream Products

• 1050520-88-1 1-(4-(benzyloxy)phenyl)-2-((1-adamantylmethyl)amino)ethanol 
• 1050520-90-5 4-(2-((1-adamantylmethyl)amino)-1-hydroxyethyl)phenol 
• 1050520-85-8 3-adamantan-1-ylmethyl-5-(4-hydroxy-phenyl)-oxazolidin-2-one 
• 1050521-14-6 4-(2-(1-adamantylmethylamino)-1-hydroxyethyl)cyclohexanol 
• 61439-59-6 2-(4-benzyloxyphenyl)ethanol 
• 577776-39-7 ethyl 4-[4-(benzyloxy)phenyl]-3-oxobutanoate 
• 55708-62-8 N-(4'-benzyloxy-β-methoxyphenethyl)-3-benzyloxy-4-methoxy-N-methylbenzylamine 
• 344598-19-2 4-{2-[(3-Benzyloxy-4-methoxy-benzyl)-methyl-amino]-1-methoxy-ethyl}-phenol 
• 88741-55-3 β-(4-benzyloxyphenyl)-β-methoxyethyl methanesulfonate 
• 26996-80-5 4-(4-hydroxyphenyl)-7-hydroxy-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline 
• 88741-54-2 β-4-(benzyloxyphenyl)-β-methoxyethylalcohol 

Relevant articles and documents

Preparation method of 2-(4-benzyloxyphenyl)ethanol

The invention provides a preparation method of 2-(4-benzyloxyphenyl)ethanol. The preparation method comprises the following steps: 1) subjecting phenol to reacting with chloroacetyl chloride under the catalysis of aluminum trichloride to obtain a compound as shown in a formula II; 2) subjecting the compound as shown in the formula II to reacting with benzyl halide under an alkaline condition to obtain a compound as shown in a formula III, wherein the benzyl halide is one selected from benzyl bromide and benzyl chloride; 3) performing reduction treatment on the compound as shown in the formula III, and adjusting a reaction system to be an alkaline system to obtain a compound as shown in a formula IV; and 4) under the action of a catalyst, reducing the compound as shown in the formula IV under a hydrogen condition to obtain the 2-(4-benzyloxyphenyl)ethanol as shown in the formula I. The preparation method has the advantages of low cost, mild reaction conditions, safety in operation and less three-waste pollution, and is beneficial to being applied to industrial production.

CYCLIC UREA AND CARBAMATE INHIBITORS OF 11β -HYDROXYSTEROID DEHYDROGENASE 1

This invention relates to novel compounds of the Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11 beta-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of Cortisol in a cell or the inhibition of the conversion of cortisone to Cortisol in a cell.