72734-85-1

Basic information

• Product Name: 1-(3-chloropropyl)-2-methoxybenzene
• Synonyms: 1-(3-chloropropyl)-2-methoxybenzene
• CAS NO: 72734-85-1
• Molecular Weight: 184.666
• Mol File: 72734-85-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(3-chloropropyl)-2-methoxybenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-chloropropyl)-2-methoxybenzene(72734-85-1)
• EPA Substance Registry System: 1-(3-chloropropyl)-2-methoxybenzene(72734-85-1)

Safety Data

• Hazardous Substances Data: 72734-85-1(Hazardous Substances Data)

Usage

Chemical structure

1-(3-chloropropyl)-2-methoxybenzene consists of a benzene ring with a methoxy group (-OCH3) and a chloropropyl group (-CH2CH2CH2Cl) attached to it.

Usage

Commonly used in the production of industrial chemicals and pharmaceuticals.

Intermediate role

Often used as an intermediate in the manufacturing of various products, such as dyes, fragrances, and pharmaceuticals.

Hazardous nature

It can be hazardous if not used properly.

Potential health risks

Can cause irritation to the skin, eyes, and respiratory system.

Safety precautions

It is important to handle this chemical with care to minimize exposure and potential health risks.

Upstream product

• 70311-27-2 2-methoxybenzenepropanoic acid ethyl ester 
• 55001-09-7 methyl 3-(2-methoxyphenyl)propanoate 
• 1481-92-1 2-(3-hydroxypropyl)phenol 
• 6342-77-4 2-methoxy-benzenepropanoic acid 
• 10493-37-5 3-(2-methoxyphenyl)propan-1-ol 

Downstream Products

• 77853-46-4 4-(2-Methoxyphenyl)-butanenitrile 
• 33209-75-5 4-(2-Methoxyphenyl)-butanoic acid 
• 89113-48-4 1-methoxy-2-(3-methoxy-propyl)-benzene 
• 56490-36-9 (3-(2-methoxyphenyl)propyl)(methyl)sulfane 
• 17733-60-7 2-(3-Methanesulfonyl-propyl)-phenol 
• 56490-38-1 3(o-Methoxyphenyl)propylmethylsulfon 
• 56490-41-6 Acetic acid 2-(3-methanesulfonyl-propyl)-phenyl ester 
• 56490-61-0 1-[4-Hydroxy-3-(3-methanesulfonyl-propyl)-phenyl]-ethanone 
• 56490-68-7 1-[4-Benzyloxy-3-(3-methanesulfonyl-propyl)-phenyl]-ethanone 
• 56490-88-1 4-Benzyloxy-3-(methylsulfonylpropyl)-phenylglyoxal 
• 56490-77-8 1-[4-Benzyloxy-3-(3-methanesulfonyl-propyl)-phenyl]-2-bromo-ethanone 
• 154585-02-1 4-(2-methoxyphenyl)butylamine 
• 33892-75-0 5-Methoxy-1-tetralone 
• 10415-16-4 1-Allyloxy-3-[3-(2-methoxy-phenyl)-propylamino]-propan-2-ol 

Relevant articles and documents

New serotonin 5-HT1A receptor agonists endowed with antinociceptive activity in vivo

We report the synthesis of new compounds 4-35 based on two different openings (A and B) of the chromane ring present in the previously identified 5-HT1A receptor (5-HT1AR) ligand 3. The synthesized compounds were assessed for binding affinity, selectivity, and functional activity at the 5-HT1AR. Selected candidates resulting from B opening were also evaluated for their potential antinociceptive effect in vivo and pharmacokinetic properties in vitro. Analogue 19 [2-(4-{[2-(2-ethoxyphenoxy) ethyl]amino}butyl)tetrahydro-1H-pyrrolo[1,2-c]imidazole-1,3(2H)-dione] has been characterized as a high-affinity and potent 5-HT1AR agonist (K i = 2.3 nM; EC50 = 19 nM). Pharmacokinetic studies indicated that compound 19 displays a good metabolic stability in human liver microsomes (t1/2 ～ 3 h and CLint = 3.5 mL/min/kg, at 5 μM), and a low level of protein binding (25%, at 5 μM). Interestingly, 19 (3 mg/kg, ip, and 30 mg/kg, po) caused significant attenuation of formalin-induced behavior in early and late phases of the mouse intradermal formalin test of pain, and this in vivo effect was reversed by the selective 5-HT1AR antagonist WAY-100635. Thus, the new 5-HT1AR agonist identified in this work, 19, exhibits oral analgesic activity, and the results herein represent a step toward identifying new therapeutics for the control of pain.