72745-76-7

Basic information

• Product Name: 2-METHYL-1,3-BENZOXAZOL-5-AMINE
• Synonyms: 5-AMINO-2-METHYL-1,3-BENZOXAZOLE;2-METHYL-1,3-BENZOXAZOL-5-AMINE;5-AMINO-2-METHYLBENZOXAZOLE;2-methylbenzo[d]oxazol-5-amine;2-Methyl-1,3-benzoxazol-5-amine, 5-Amino-2-methylbenzo[d]oxazole
• CAS NO: 72745-76-7
• Molecular Formula: C₈H₈N₂O
• Molecular Weight: 148.16
• Product Categories: Amines;Oxazoles, Isoxazoles & Benzoxazoles;Oxazoles, Isoxazoles & Benzoxazoles
• Mol File: 72745-76-7.mol
• Article Data: 10

Chemical Properties

• Melting Point: 50-53°C
• Boiling Point: 290.6 °C at 760 mmHg
• Flash Point: 129.6 °C
• Appearance: Off-white to brown/Crystalline Powder
• Density: 1.254 g/cm³
• Vapor Pressure: 0.00205mmHg at 25°C
• Refractive Index: 1.658
• Storage Temp.: 2-8°C
• PKA: 7.38±0.10(Predicted)
• CAS DataBase Reference: 2-METHYL-1,3-BENZOXAZOL-5-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYL-1,3-BENZOXAZOL-5-AMINE(72745-76-7)
• EPA Substance Registry System: 2-METHYL-1,3-BENZOXAZOL-5-AMINE(72745-76-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-36
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 72745-76-7(Hazardous Substances Data)

Usage

General Description

2-Methyl-1,3-benzoxazol-5-amine, also known as 2-Methyl-5-amino-1,3-benzoxazole, is a chemical compound with the molecular formula C8H8N2O. It is a heterocyclic aromatic amine that is commonly used in organic synthesis and pharmaceutical research. 2-METHYL-1,3-BENZOXAZOL-5-AMINE is known to have potential biological and pharmacological activities and is being investigated for its potential use in the development of new drugs. It has been found to exhibit anti-inflammatory and analgesic properties, making it a promising candidate for the treatment of various medical conditions. Additionally, 2-methyl-1,3-benzoxazol-5-amine has also been studied for its potential application in the field of materials science, particularly in the development of novel polymers and functional materials.

InChI:InChI=1/C8H8N2O/c1-5-10-7-4-6(9)2-3-8(7)11-5/h2-4H,9H2,1H3

Upstream product

• 23184-60-3 acetic acid-(5-amino-2-hydroxy-anilide) 
• 19219-99-9 2-methyl-5-chlorobenzoxazole 
• 97-60-9 2-acetamido-4-nitrophenol 
• 99-57-0 2-hydroxy-5-nitroaniline 
• 32046-51-8 2-methyl-5-nitro-1,3-benzoxazole 

Downstream Products

• 686747-47-7 2,5-dichloro-N-(2-methylbenzooxazol-5-yl)benzenesulfonamide 
• 686747-46-6 N-(2-methylbenzooxazol-5-yl)-4-propylbenzenesulfonamide 
• 686747-45-5 3-chloro-2-methyl-N-(2-methylbenzooxazol-5-yl)benzenesulfonamide 

Relevant articles and documents

Oxalic amide ligands, and uses thereof in copper-catalyzed coupling reaction of aryl halides

The present invention provides oxalic amide ligands and uses thereof in copper-catalyzed coupling reaction of aryl halides. Specifically, the present invention provides a use of a compound represented by formula I, wherein definitions of each group are described in the specification. The compound represented by formula I can be used as a ligand in copper-catalyzed coupling reaction of aryl halides for the formation of C—N, C—O and C—S bonds.

NOVEL NICOTINAMIDE DERIVATIVES OR SALTS THEREOF

An object of the present invention is to provide to a compound and a pharmaceutical composition, which have excellent Syk-inhibitory activity. Th e present invention provides a nicotinamide derivative represented by the follo wing formula (I) (wherein R 1 represents a halogen atom; R 2 represents a C 1-12 alkyl group, a C 2-12 alkenyl group, a C 2-12 alkynyl group, a C 3-8 cycloalkyl g roup, an aryl group, an ar-C 1-6 alkyl group or a heterocyclic group, each opti onally having at least one substituent; R 3 represents an aryl group or a hetero cyclic group each optionally having at least one substituent; and R 4 and R 5 e ach independently represent a hydrogen atom; and R 2 and R 4 may form a cyc lic amino group optionally having at least one substituent together with the ni trogen atom to which they bind) or a salt thereof, and a pharmaceutical comp osition for use in the treatment of a Syk-related disease which comprises the nicotinamide derivative or a salt thereof.

ANTI-VIRAL COMPOUNDS

Described herein are compounds and related compositions for the treatment of viral infections, including RNA viral infection, and compounds that can modulate the RIG-I pathway in vertebrate cells,including compounds that can activate the RIG-I pathway.