72753-31-2

Basic information

• Product Name: BENZYL-(4-ETHOXY-PHENYL)-AMINE
• Synonyms: BENZYL-(4-ETHOXY-PHENYL)-AMINE;Benzenemethanamine,N-(4-ethoxyphenyl)-;Benzyl-(4-Ethoxy-Phenyl)-Amine(WXC02964)
• CAS NO: 72753-31-2
• Molecular Formula: C₁₅H₁₇NO
• Molecular Weight: 227.30158
• Mol File: 72753-31-2.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: BENZYL-(4-ETHOXY-PHENYL)-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: BENZYL-(4-ETHOXY-PHENYL)-AMINE(72753-31-2)
• EPA Substance Registry System: BENZYL-(4-ETHOXY-PHENYL)-AMINE(72753-31-2)

Safety Data

• Hazardous Substances Data: 72753-31-2(Hazardous Substances Data)

Usage

General Description

Benzyl-(4-ethoxy-phenyl)-amine is a chemical compound with the molecular formula C15H17NO. It is commonly used as a building block in the synthesis of various pharmaceuticals and organic compounds. This chemical is a member of the amine class, which means it contains a nitrogen atom bonded to carbon atoms. Benzyl-(4-ethoxy-phenyl)-amine has a benzene ring and an ethoxy group attached to a phenyl ring, along with a benzyl group attached to the amine nitrogen atom. It may have potential applications in the field of medicinal chemistry and drug discovery due to its structural features and functional groups. Additionally, it can be used in the production of dyes, polymers, and other industrial products.

Upstream product

• 538-51-2 benzylidene phenylamine 
• 156-43-4 4-Ethoxyaniline 
• 100-51-6 benzyl alcohol 
• 100-52-7 benzaldehyde 
• 15484-91-0 N-benzylidene-4-ethoxyaniline 
• 100-44-7 benzyl chloride 

Downstream Products

• 102449-03-6 6-ethoxy-9-benzyl-1,2,3,4-tetrahydro-carbazole 
• 346577-63-7 N-benzyl-N-(4-ethoxyphenyl)-2-diazo-3-oxobutanamide 
• 346577-70-6 N-benzyl-2-diazo-N-(4-ethoxy-phenyl)-malonamic acid methyl ester 
• 1422969-32-1 N¹,N⁴-dibenzyl-N¹,N⁴-bis(4-ethoxyphenyl)fumaramide 
• 185913-78-4 1-[4-(N-tert-butyl-carbamoyl)-2-methoxybenzene sulphonyl]-5-ethoxy-3-spiro-[4-(2-morpholinoethoxy)cyclohexane]indol-2-one; equatorial isomer 
• 185913-78-4 1'-[2-methoxy-4-(tert-butylaminocarboxamido)benzenesulfonyl]-5'-ethoxy-4-[2-(4-morpholino)ethoxy]spiro[cyclohexane-1,3'-indolin]-2'-one 
• 346577-69-3 1'-benzyl-5'-ethoxy-4-[2-(4-morpholino)ethoxy]spiro[cyclohexane-1,3'-indolin]-2'-one 
• 346577-71-7 1'-benzyl-5'-ethoxy-4-[2-(4-morpholino)ethoxy]spiro[cyclohexane-1,3'-indolin]-2'-one 
• 346577-66-0 1'-benzyl-5'-ethoxyspiro[cyclohexane-1,3'-indoline]-4,2'-dione cyclic 4-ethylene ketal 
• 346577-68-2 1'-benzyl-5'-ethoxy-4-hydroxyspiro[cyclohexane-1,3'-indolin]-2'-one 
• 346577-67-1 1′-benzyl-5′-ethoxyspiro[cyclohexane-1,3′-indoline]-2′,4-dione 
• 948551-98-2 1'-benzyl-5'-ethoxy-4-hydroxyspiro[cyclohexane-1,3'-indolin]-2'-one 
• 346577-65-9 1-benzyl-5-ethoxy-2-indolinone 
• 346577-64-8 N-benzyl-N-(4-ethoxyphenyl)diazoacetamide 

Relevant articles and documents

Tungsten-Catalyzed Direct N-Alkylation of Anilines with Alcohols

The implementation of non-noble metals mediated chemistry is a major goal in homogeneous catalysis. Borrowing hydrogen/hydrogen autotransfer (BH/HA) reaction, as a straightforward and sustainable synthetic method, has attracted considerable attention in the development of non-noble metal catalysts. Herein, we report a tungsten-catalyzed N-alkylation reaction of anilines with primary alcohols via BH/HA. This phosphine-free W(phen)(CO)4 (phen=1,10-phenthroline) system was demonstrated as a practical and easily accessible in-situ catalysis for a broad range of amines and alcohols (up to 49 examples, including 16 previously undisclosed products). Notably, this tungsten system can tolerate numerous functional groups, especially the challenging substrates with sterically hindered substituents, or heteroatoms. Mechanistic insights based on experimental and computational studies are also provided.

Scalable synthesis of secondary and tertiary amines by heterogeneous Pt-Sn/γ-Al2O3catalyzed N-alkylation of amines with alcohols

Synthesis of secondary and tertiary amines has been efficiently realized from the N-alkylation of amines with alcohols by means of heterogeneous bimetallic Pt-Sn/γ-Al2O3catalyst (0.5?wt % Pt, molar ratio Pt:Sn?=?1:3) through a borrowing hydrogen strategy. The Pt-Sn/γ-Al2O3catalyst has exhibited very high catalytic activity towards a wide range of amines and alcohols, and can be conveniently recycled without Pt metal leaching. The present protocol was applied for the synthesis of N-phenylbenzylamine in 96% isolated yield from aniline and benzyl alcohol on a 2.1?kg scale of the substrates, demonstrating its potential applicability for higher-order amine synthesis.

Nano-sized NiLa2O4 spinel-NaBH4-mediated reduction of imines to secondary amines

Nano-sized NiLa2O4 spinel was produced by thermal decomposition of Ni-La compounds via a sol-gel method. The well-crystallized spinel structure was formed after calcination at 750 °C. The physicochemical properties of the spinel were investigated using differential thermal analysis, X-ray diffraction, transmission electron microscopy, scanning electron microscopy, and particle size distribution analysis. The results show that the nanoparticles have regular shapes with well-defined crystal faces and consist of uniform quasi-spherical crystallites of average size 40 nm. The refined unit cell parameters are a = 3.861205 ? and c = 12.6793 ?. This new nano-sized NiLa2O4 spinel is an efficient heterogeneous catalyst for the selective conversion of imines to the corresponding secondary amines in the presence of NaBH4 as a reducing agent, in good to excellent yields. All the reactions were completely chemoselective at room temperature and had relatively short reaction times. Secondary amines with different aryl groups, including those bearing electron-withdrawing or electron-donating groups, were obtained under the optimum reaction conditions. The catalyst was readily recovered and was recycled four times with no significant loss of catalytic activity.