72785-16-1Relevant articles and documents
METHOD F0R THE PURIFICATION OF CYCLOHEXADEC-8-EN-1-ONE
-
Paragraph 0177; 0178; 0180, (2018/11/21)
The present invention relates to a novel method for purifying cyclohexadec-8-en-1-one, a method for preparing cyclohexadec-8-en-1-one and cyclopentadecenones, the substances and substance mixtures prepared therefrom and use thereof as aroma substances, particularly as fragrances, and also aroma substance compositions and agents comprising these mixtures.
Macrocycles by ring-closing metathesis
Fürstner, Alois,Langemann, Klaus
, p. 792 - 803 (2007/10/03)
The ruthenium carbene complexes 1 and 2 (0.05-5 mol %) catalyse highly efficient macrocyclization reactions of 1,ω-dienes by ring-closing metathesis (RCM). Key parameters for successful RCM are (i) the presence of a functional group which serves as a relay entity that assembles the reacting sites, (ii) an appropriate distance between this polar group and the alkenes to be metathesized, and (iii) low steric congestion near the double bonds. Contrary to previous assumptions, however, the ring size formed and the conformational predisposition of the substrates for ring closure turned out to be of minor importance. These aspects are illustrated by some straightforward syntheses of macrocyclic lactones, lactams, ethers and ketones, including the musk odored perfume ingredients Exaltolide, Exaltone and Arova 16, of the macrolide recifeiolide (24), as well as of the alkaloids epilachnene (40) and its homologue 9-propyl-10-azacyclododecan-12-olide (39), which are active principles of the defense secretions of the pupae of the mexican beetle Epilachnar varivestis.
