72801-60-6Relevant articles and documents
Antiulcer Agents. 4-Substituted 2-Guanidinothiazoles: Reversible, Competitive, and Selective Inhibitors of Gastric H+,K+-ATPase
LaMattina, John L.,McCarthy, Peter A.,Reiter, Lawrence A.,Holt, William F.,Yeh, Li-An
, p. 543 - 552 (2007/10/02)
A series of 4-substituted 2-guanidinothiazoles has been found to inhibit the gastric proton-pump enzyme H+,K+-ATPase.In general, these compounds were reversible inhibitors of canine gastric H+,K+-ATPase, competi
Conformational requirements for histamine H2-receptor inhibitors: A structure-activity study of phenylene analogues related to cimetidine and tiotidine
Hoffman,Pietruszkiewicz,Habecker,Phillips,Bolhofer,Cragoe Jr.,Torchiana,Lumma Jr.,Baldwin
, p. 140 - 144 (2007/10/02)
Two series of compounds related to cimetidine and tiotidine were synthesized as part of a study to evaluate the importance of conformational parameters in binding at histamine H2 receptors. The flexible methylthioethyl connecting chain was repl