72817-97-1

Basic information

• Product Name: ethyl 4-amino-5-cyanosalicylate
• Synonyms: ethyl 4-amino-5-cyanosalicylate;Benzoic acid, 4-amino-5-cyano-2-hydroxy-, ethyl ester (9CI);2-Hydroxy-4-amino-5-cyanobenzoic acid ethyl ester;4-Amino-5-cyano-2-hydroxybenzoic acid ethyl ester;Benzoic acid, 4-aMino-5-cyano-2-hydroxy-, ethyl ester;Ethyl 4-aMino-5-cyano-2-hydroxybenzoate
• CAS NO: 72817-97-1
• Molecular Formula: C₁₀H₁₀N₂O₃
• Molecular Weight: 206.198
• EINECS: 276-867-6
• Product Categories: AMINOACID
• Mol File: 72817-97-1.mol
• Article Data: 4

Chemical Properties

• Melting Point: 185-187 °C(Solv: acetic acid (64-19-7))
• Boiling Point: 420.9ºC at 760 mmHg
• Flash Point: 208.4ºC
• Appearance: /
• Density: 1.34g/cm3
• Vapor Pressure: 1.11E-07mmHg at 25°C
• Refractive Index: 1.597
• Storage Temp.: 2-8°C
• PKA: 7.87±0.23(Predicted)
• CAS DataBase Reference: ethyl 4-amino-5-cyanosalicylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-amino-5-cyanosalicylate(72817-97-1)
• EPA Substance Registry System: ethyl 4-amino-5-cyanosalicylate(72817-97-1)

Safety Data

• Hazardous Substances Data: 72817-97-1(Hazardous Substances Data)

Usage

Description

Ethyl 4-amino-5-cyanosalicylate is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceutical compounds. It is characterized by its unique molecular structure, which includes an ethyl group, an amino group, a cyano group, and a salicylate group. ethyl 4-amino-5-cyanosalicylate plays a significant role in the development of drugs with potent therapeutic properties.

Uses

Used in Pharmaceutical Industry:
Ethyl 4-amino-5-cyanosalicylate is used as an intermediate in the synthesis of 4-Amino-6-hydroxy-1,3-benzenedicarboxylic Acid (A634570), a compound with tuberculostatic activity. It is employed for the development of drugs targeting tuberculosis, a significant global health concern.
Additionally, ethyl 4-amino-5-cyanosalicylate is used as an intermediate in the synthesis of compounds with antimalarial activity. Malaria is a life-threatening disease caused by parasites that are transmitted to humans through the bites of infected mosquitoes. The development of drugs using this compound can contribute to the fight against malaria, which affects millions of people worldwide.

InChI:InChI=1/C10H10N2O3/c1-2-15-10(14)7-3-6(5-11)8(12)4-9(7)13/h3-4,13H,2,12H2,1H3

Upstream product

• 49836-24-0 (E)-2-(ethoxymethylene)-3-oxobutanoic acid ethyl ester 
• 109-77-3 malononitrile 
• 3788-94-1 2-ethoxymethylene-3-oxobutanoic acid ethyl ester 
• 141-97-9 ethyl acetoacetate 
• 123-06-8 Ethoxymethylenemalononitrile 

Downstream Products

• 15540-79-1 4-amino-6-hydroxyisophthalic acid 
• 72817-93-7 4-Amino-5-cyano-salicylsaeure 
• 72817-87-9 4-Amino-5-cyansalicylsaeureamid 
• 72817-90-4 4-Amino-5-carbamoylsalicylsaeure-ethylester 
• 105290-53-7 ethyl 4-chloro-5-cyano-2-hydroxybenzoate 
• 105290-54-8 4-Brom-5-cyan-salicylsaeure-ethylester 
• 105290-55-9 5-cyano-2-hydroxy-4-iodo-benzoic acid ethyl ester 
• 85946-11-8 4-Amino-3-brom-5-cyan-salicylsaeure-ethylester 
• 105290-52-6 4-Amino-5-cyan-3-jod-salicylsaeure-ethylester 
• 681466-47-7 2-allyloxy-5-cyano-4-iodo-benzoic acid 
• 681466-45-5 2-allyloxy-5-cyano-4-iodo-benzoic acid ethyl ester 
• 55488-82-9 4-Chlor-5-cyan-salicylsaeure 

Relevant articles and documents

PESTICIDALLY ACTIVE CYCLIC AMINE COMPOUNDS

Compounds of formula (I) wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides.

SULPHOXIMINE-SUBSTITUTED QUINAZOLINE DERIVATIVES AS IMMUNO-MODULATORS, THEIR PREPARATION AND USE AS MEDICAMENTS

The present invention relates to sulphoximine-substituted quinazoline derivatives of the formula (I), processes for their preparation and their use as a medicament for the treatment of various diseases.