729-43-1

Basic information

• Product Name: ACETOPHENONE AZINE
• Synonyms: (1E)-1-Phenylethanone [(E)-1-phenylethylidene]hydrazone;1-phenyl-ethanon(1-phenylethylidene)hydrazone;Ethanone, 1-phenyl-, azine;TIMTEC-BB SBB007897;BENZOYL METHIDE AZINE;HYPNONE AZINE;METHYL PHENYL KETONE AZINE;ACETYLBENZENE AZINE
• CAS NO: 729-43-1
• Molecular Formula: C₁₆H₁₆N₂
• Molecular Weight: 236.31
• EINECS: 211-979-0
• Product Categories: Aromatic Acetophenones & Derivatives (substituted)
• Mol File: 729-43-1.mol
• Article Data: 54

Chemical Properties

• Melting Point: 121-122°C
• Boiling Point: 333.2 °C at 760 mmHg
• Flash Point: 147.4 °C
• Appearance: /
• Density: 0.98 g/cm³
• Vapor Pressure: 0.000268mmHg at 25°C
• Refractive Index: 1.551
• PKA: 7.63±0.50(Predicted)
• BRN: 1912471
• CAS DataBase Reference: ACETOPHENONE AZINE(CAS DataBase Reference)
• NIST Chemistry Reference: ACETOPHENONE AZINE(729-43-1)
• EPA Substance Registry System: ACETOPHENONE AZINE(729-43-1)

Safety Data

• Safety Statements: 22-24/25
• TSCA: Yes
• Hazardous Substances Data: 729-43-1(Hazardous Substances Data)

Usage

General Description

Acetophenone Azine is a chemical compound that is categorized under the class of azines, which are organic compounds containing two or more compounds where three nitrogen atoms are each attached to the other one. The compound exists as a light yellow crystalline powder that appears needle-like, which has a specific pungent smell. Being light-sensitive, it should be stored in a dark place. It has a melting point of 72-75°C and a boiling point of around 168-169°C. Acetophenone Azine is primarily used in the production of pharmaceuticals, organic synthesis, and as a preservative in perfumery. It requires careful handling due to its potential health hazards such as skin and eye irritation. Its chemical formula is (C6H5COCH3)2N2.

InChI:InChI=1/C16H16N2/c1-13(15-9-5-3-6-10-15)17-18-14(2)16-11-7-4-8-12-16/h3-12H,1-2H3/b17-13+,18-14+

Upstream product

• 64-17-5 ethanol 
• 26323-94-4 bis-(1-phenyl-ethylidene)-carbonohydrazide 
• 2492-30-0 acetophenone semicarbazone 
• 108-24-7 acetic anhydride 
• 22293-10-3 (1-diazoethyl)benzene 
• 65-85-0 benzoic acid 
• 99-90-1 para-bromoacetophenone 
• 7803-57-8 hydrazine hydrate 
• 56352-60-4 oxalamic acid-(1-phenyl-ethylidenehydrazide) 
• 100-46-9 benzylamine 
• 98-86-2 acetophenone 
• 613-91-2 acetophenone oxime 
• 75-16-1 methylmagnesium bromide 
• 100-47-0 benzonitrile 

Downstream Products

• 126434-01-3 phenyl 3,3,3-trichloro-2(phenylsulfonylamino)propyl ketone azine 
• 25445-77-6 4-phenyl-1,2,3-thiadiazole 
• 618-34-8 1-chlorostyrene 
• 98-86-2 acetophenone 
• 838-40-4 2,5-diphenyl-1H-pyrrole 
• 891-22-5 3,6-diphenylpyridazine 
• 840-04-0 1-methyl-2,5-diphenyl-pyrrole 
• 23990-17-2 3,6-diphenyl-1,4-dihydropyridazine 
• 13280-20-1 1-phenylethanimine 
• 113522-02-4 1-methyl-4-phenyl-1,2,3,4-tetrahydrophthalazine 
• 113522-03-5 1-methyl-4-phenyldihydrophthalazine 
• 100-47-0 benzonitrile 
• 16350-54-2 1-methyl-4-phenyl-phthalazine 
• 94801-46-4 N,N'-bis-(1-phenyl-ethyl)-hydrazine 

Relevant articles and documents

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Gold(I) complexes bearing ring-fused benzoxazine-derived triazolylidenes and their use in C–N bond-forming processes

We report the synthesis and full characterization of a novel series of ring-fused benzoxazine-derived triazolium salts (1a–c) and their corresponding triazolylidene gold(I) complexes (2a–c). All new compounds were fully characterized by means of 1H and 13C NMR spectroscopy, elemental analyses, and mass spectroscopy and in the case of triazoliums 1a and 1b by single-crystal X-ray diffraction. The new triazolylidene gold complexes (2a–c) were tested as precatalysts in the hydroamination and hydrohydrazination of terminal alkynes employing aniline derivatives and hydrazine as nitrogen sources, respectively.

Palladium-Catalyzed Regioselective Acylation of Diazines with Toluenes: A New Approach to the Synthesis of ortho-Diacylbenzenes

A highly efficient and practical procedure for chemo- and regioselective synthesis of ortho-diacylbenzenes through Pd-catalyzed oxidative C–H bond activation has been developed. Using this method, a variety of ortho-diacylbenzenes were prepared in moderate to good yields, by direct acylation of diazines with toluene derivatives as acylation source. Ortho-diacylbenzenes may be used as precursors in synthesis of pharmaceuticals and agrochemicals.

Unprecedented synthesis of symmetrical azines from alcohols and hydrazine hydrate using nickel based NNN-pincer catalyst: An experimental and computational study

Azines are having widespread applications in both industry as well as synthetic chemistry. Thus new catalytic synthetic protocols are desirable as they are greener alternatives than traditional methods of synthesis. Thus, herein a novel earth abundant nickel based NNN-pincer catalyst Ni(BPEA)(Cl2) is synthesized for the first time for the direct transformation of alcohols and hydrazine hydrate into symmetrical azines. This catalytic reaction is accompanied by dehydrogenative coupling of alcohols and hydrazine hydrate and is carried out in presence of a base. Theoretical calculations supported by experimental evidence have been performed for understanding the mechanistic insights of the reaction.