72922-60-2

Basic information

• Product Name: Methyl3-aMino-4-Methyl-5-nitrobenzoate
• Synonyms: Methyl3-aMino-4-Methyl-5-nitrobenzoate;Benzoic acid, 3-aMino-4-Methyl-5-nitro-, Methyl ester
• CAS NO: 72922-60-2
• Molecular Formula: C₉H₁₀N₂O₄
• Molecular Weight: 210.1867
• Mol File: 72922-60-2.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Methyl3-aMino-4-Methyl-5-nitrobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl3-aMino-4-Methyl-5-nitrobenzoate(72922-60-2)
• EPA Substance Registry System: Methyl3-aMino-4-Methyl-5-nitrobenzoate(72922-60-2)

Safety Data

• Hazardous Substances Data: 72922-60-2(Hazardous Substances Data)

Usage

General Description

Methyl-3-amino-4-methyl-5-nitrobenzoate is a chemical compound with a formula of C9H10N2O4. As suggested by its name, it has three functional groups: a methyl group (-CH3), an amino group (-NH2), and a nitro group (-NO2), attached to a benzoate structure. Methyl3-aMino-4-Methyl-5-nitrobenzoate is unique because it simultaneously contains these different groups, each contributing distinct properties. It's likely used in various organic synthesis reactions, given its chemical structure. However, specific information regarding its reaction characteristics, properties, and applications are not broadly available and may be subject to proprietary research or specific applications in the field of chemistry.

Upstream product

• 16533-71-4 3,5-dinitro-p-toluic acid 
• 49592-71-4 methyl 4-methyl-3,5-dinitrobenzoate 

Downstream Products

• 1057652-84-2 methyl 3-chloro-4-methyl-5-nitrobenzoate 
• 1057652-89-7 Methyl 3-fluoro-4-methyl-5-nitro-benzoate 
• 1070887-37-4 C₁₁H₁₃NO₅ 
• 1070887-44-3 C₁₂H₁₅NO₅ 
• 1057652-85-3 methyl 4-bromomethyl-3-chloro-5-nitro-benzoate 
• 1070886-76-8 C₂₀H₂₆ClNO₈ 
• 1070886-77-9 C₁₁H₁₀ClNO₆ 
• 1070886-78-0 C₁₇H₁₄Cl₂N₂O₅ 
• 1070886-79-1 C₁₇H₁₆Cl₂N₂O₃ 
• 1070885-59-4 C₂₇H₂₈Cl₂N₄O₄S 
• 1070886-45-1 C₁₂H₁₀ClNO₈ 
• 1070886-33-7 C₂₆H₂₆Cl₂N₄O₄S 
• 54591-64-9 3-hydroxy-4-methyl-5-nitrobenzoic acid 
• 33713-02-9 3-methoxy-4-methyl-5-nitrobenzoic acid methyl ester 

Relevant articles and documents

X-ray Structure-Guided Discovery of a Potent, Orally Bioavailable, Dual Human Indoleamine/Tryptophan 2,3-Dioxygenase (hIDO/hTDO) Inhibitor That Shows Activity in a Mouse Model of Parkinson’s Disease

Human indoleamine 2,3-dioxygenase 1 (hIDO1) and tryptophan 2,3-dioxygenase (hTDO) have been closely linked to the pathogenesis of Parkinson’s disease (PD); nevertheless, development of dual hIDO1 and hTDO inhibitors to evaluate their potential efficacy against PD is still lacking. Here, we report biochemical, biophysical, and computational analyses revealing that 1H-indazole-4-amines inhibit both hIDO1 and hTDO by a mechanism involving direct coordination with the heme ferrous and ferric states. Crystal structure-guided optimization led to23, which manifested IC50values of 0.64 and 0.04 μM to hIDO1 and hTDO, respectively, and had good pharmacokinetic properties and brain penetration in mice.23showed efficacy against the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse motor coordination deficits, comparable to Madopar, an anti-PD medicine. Further studies revealed that different from Madopar,23likely has specific anti-PD mechanisms involving lowering IDO1 expression, alleviating dopaminergic neurodegeneration, reducing inflammatory cytokines and quinolinic acid in mouse brain, and increasing kynurenic acid in mouse blood.

TYK2 INHIBITORS AND USES THEREOF

Described herein are compounds that are useful in treating a TYK2-mediated disorder. In some embodiments, the TYK2-mediated disorder is an autoimmune disorder, an inflammatory disorder, a proliferative disorder, an endocrine disorder, a neurological disorder, or a disorder associated with transplantation.

Orally active zwitterionic factor Xa inhibitors with long duration of action

We have optimized 2-aminomethylphenylamine derivative as a factor Xa inhibitor. Several polar functional groups were introduced in the central phenyl ring, and we focused on zwitter ionic compound showing continuous inhibitory activity in oral administrat