72922-83-9

Basic information

• Product Name: 2-Pyrrolidinecarbonyl chloride, 1-(phenylsulfonyl)-, (S)-
• CAS NO: 72922-83-9
• Molecular Formula: C11H12ClNO3S
• Molecular Weight: 273.74
• Mol File: 72922-83-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-Pyrrolidinecarbonyl chloride, 1-(phenylsulfonyl)-, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyrrolidinecarbonyl chloride, 1-(phenylsulfonyl)-, (S)-(72922-83-9)
• EPA Substance Registry System: 2-Pyrrolidinecarbonyl chloride, 1-(phenylsulfonyl)-, (S)-(72922-83-9)

Safety Data

• Hazardous Substances Data: 72922-83-9(Hazardous Substances Data)

Upstream product

• 98-09-9 benzenesulfonyl chloride 
• 147-85-3 L-proline 
• 88425-46-1 L-(phenylsulfonyl)proline 
• 88425-46-1 N-benzenesulfonyl-L-proline 

Downstream Products

• 1198399-07-3 2-(S)-1-benzenesulfonylpyrrolidine-2-carbonitrile 
• 1257059-57-6 3-(1-benzenesulfonylpyrrolidin-2-yl)-1,2,4-oxadiazole 
• 1257059-58-7 5-methyl-3-(1-benzenesulfonylpyrrolidin-2-yl)-1,2,4-oxadiazole 
• 1257059-59-8 5-phenyl-3-(1-benzenesulfonylpyrrolidin-2-yl)-1,2,4-oxadiazole 
• 1257059-60-1 5-p-tolyl-3-(1-benzenesulfonylpyrrolidin-2-yl)-1,2,4-oxadiazole 
• 1257059-61-2 5-(4-methoxyphenyl)-3-(1-benzenesulfonylpyrrolidin-2-yl)-1,2,4-oxadiazole 
• 1257059-62-3 5-(2-chlorophenyl)-3-(1-benzenesulfonylpyrrolidin-2-yl)-1,2,4-oxadiazole 
• 1257059-63-4 5-(2-cyanophenyl)-3-(1-benzenesulfonylpyrrolidin-2-yl)-1,2,4-oxadiazole 
• 1254975-30-8 (2'S,5R)-5-isopropyl-3-(1'-benzenesulfonylpyrrolidin-2'-yl)-4,5-dihydro-1,2,4-oxadiazin-6-one 
• 1254975-31-9 (2'S,5R)-5-isobutyl-3-(1'-benzenesulfonylpyrrolidin-2'-yl)-4,5-dihydro-1,2,4-oxadiazin-6-one 
• 1254975-32-0 (2'S,5R)-5-sec-butyl-3-(1'-benzenesulfonylpyrrolidin-2'-yl)-4,5-dihydro-1,2,4-oxadiazin-6-one 
• 1254975-33-1 (2'S,5R)-5-benzyl-3-(1'-benzenesulfonylpyrrolidin-2'-yl)-4,5-dihydro-1,2,4-oxadiazin-6-one 
• 1254975-34-2 (2'S)-5-isopropyl-3-(1'-benzenesulfonylpyrrolidin-2'-yl)-4,5-dihydro-1,2,4-oxadiazin-6-one 
• 1254975-29-5 (2'S,5R)-5-methyl-3-(1'-benzenesulfonylpyrrolidin-2'-yl)-4,5-dihydro-1,2,4-oxadiazin-6-one 

Relevant articles and documents

New chiral aminoamidoximes: Syntheses and investigation of heterocyclic compounds

New chiral aminoamidoximes were prepared from (L)-proline, (L)-alanine, and (L)-isoleucine by treatment of the corresponding aminonitriles with hydroxylamine in the presence of triethylamine. The intramolecular cyclization with α-bromoacid chlorides and aldehydes was investigated to give new 1,2,4-oxadiazin-6-ones and 1,2,4-oxadiazoles, respectively. These compounds were likely to undergo an intermolecular cyclization through oxygen and nitrogen. However, intramolecular cyclization through two nitrogens did not occur even after changing reaction conditions. Taylor & Francis Group, LLC.

Unified route to the palmarumycin and preussomerin natural products. Enantioselective synthesis of (-)-preussomerin G

The total syntheses of eight members of the palmarumycin family have been achieved, with identification of the absolute stereochemistry for three of these natural products. In addition, the ras-farnesyl transferase inhibitor (-)-preussomerin G has been synthesized, achieving the first enantioselective route for accessing this family of natural products. Highlights of the synthetic work include an asymmetric epoxidation of a cyclic enone in excellent yield and enantiomeric excess and a potentially biomimetic oxidative spirocyclization for the introduction of the bis-spiroketal array unique to the preussomerin natural products.

Synthesis and Liquid Chromatographic Evalution of Some Chiral Derivatizing Agents for Resolution of Amine Enantiomers

A series of 1-prolyl chlorides were synthesized and evaluated as chiral derivatizing agents for the liquid chromatographic analysis of enantiomeric amines.The diastereomeric 1-prolinamides showed st