72934-40-8

Basic information

• Product Name: 1-(4-Methoxyphenyl)cyclopropanamine
• Synonyms: 1-(4-METHOXYPHENYL)CYCLOPROPANAMINE;1-(4-METHOXY-PHENYL)-CYCLOPROPYLAMINE;Cyclopropanamine, 1-(4-methoxyphenyl)-;1-(4-Methoxyphenyl)cyclopropan-1-aMine
• CAS NO: 72934-40-8
• Molecular Formula: C₁₀H₁₃NO
• Molecular Weight: 163.22
• EINECS: 200-258-5
• Mol File: 72934-40-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 257.3 °C at 760 mmHg
• Flash Point: 111.6 °C
• Appearance: /
• Density: 1.107 g/cm³
• Vapor Pressure: 0.0147mmHg at 25°C
• Refractive Index: 1.57
• Storage Temp.: 2-8°C
• PKA: 8.04±0.20(Predicted)
• CAS DataBase Reference: 1-(4-Methoxyphenyl)cyclopropanamine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Methoxyphenyl)cyclopropanamine(72934-40-8)
• EPA Substance Registry System: 1-(4-Methoxyphenyl)cyclopropanamine(72934-40-8)

Safety Data

• Hazardous Substances Data: 72934-40-8(Hazardous Substances Data)

Usage

General Description

1-(4-Methoxyphenyl)cyclopropanamine is a chemical compound with the molecular formula C10H13NO. It is a cyclopropanamine derivative with a 4-methoxyphenyl group, and it has the potential to be used in organic synthesis and pharmaceutical research. 1-(4-Methoxyphenyl)cyclopropanamine is a member of the amine class of organic compounds, and its chemical structure includes a cyclopropane ring and an amino group. Its primary application is in the development of new drugs and pharmaceuticals, as well as in the production of various organic compounds through synthetic processes. Additionally, it may have potential uses in the field of medicinal chemistry and drug design due to its unique chemical structure and properties.

InChI:InChI=1/C10H13NO/c1-12-9-4-2-8(3-5-9)10(11)6-7-10/h2-5H,6-7,11H2,1H3

Upstream product

• 925-90-6 ethylmagnesium bromide 
• 874-90-8 4-methoxybenzonitrile 
• 16728-01-1 1-(4-methoxyphenyl)-1-cyclopropanecarboxylic acid 

Downstream Products

• 65374-28-9 1-Azido-1-(4-methoxyphenyl)-cyclopropan 
• 1357456-14-4 C₃₀H₃₅ClN₄O₂S 
• 1266158-02-4 4-(1-aminocyclopropyl)phenol 
• 1394918-80-9 C₁₄H₁₉NO₃ 

Relevant articles and documents

COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF BROMODOMAIN-CONTAINING PROTEINS

The present invention relates to bifunctional compounds, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention. In particular, the present invention is directed to compounds, which contain on one end a VHL ligand which binds to the ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. The present invention exhibits a broad range of pharmacological activities associated with compounds according to the present invention, consistent with the degradation/inhibition of targeted polypeptides.

3-[5-substituted benzyl)amino]-2-phenylpiperidines as substance P antagonists

This invention provides a compound of the formula: STR1 and its pharmaceutically acceptable salts, wherein R 1 is C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, halo C 1 -C 6 alkyl or terahydropyranyl, having one or more substituents selected from cyano, 1,3-thiazolanyl, COOR 2, COR 2, OCOR 2, CONR 3 R 4, NR 3 R 4, NR 5 COR 3 and C.ident.CR 6, wherein R 2 is hydrogen or C 1 -C 4 alkyl, R 3 and R 4 are independently hydrogen, C 1 -C 4 alkyl or C 3 -C 6 cycloalkyl, R 5 is C 1 -C 4 alkyl or C 3 -C 6 cycloalkyl and R 6 is hydrogen, halo, cyano, C 1 -C 6 alkyl, COOH, COO(C 1 -C 4 alkyl) or phenyl; X is C 1 -C 6 alkoxy or halo C 1 -C 6 alkoxy; and Ar is phenyl optionally substituted with halo.These compounds are useful in the treatment of allergic disorders, angiogenesis, gastrointestinal disorders, central nervous system disorders, inflammatory diseases, emesis, urinary incontinence, pain, migraine, sunburn, and diseases, disorders and adverse conditions caused by Helicobacter pylori, in a mammalian subject.