729609-97-6

Basic information

• Product Name: methanesulfonic acid 3-{3-[4-(2-chloro-phenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-pyrrolo[2,3-b]pyridin-1-yl}-propyl ester
• CAS NO: 729609-97-6
• Molecular Weight: 459.91
• Mol File: 729609-97-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methanesulfonic acid 3-{3-[4-(2-chloro-phenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-pyrrolo[2,3-b]pyridin-1-yl}-propyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: methanesulfonic acid 3-{3-[4-(2-chloro-phenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-pyrrolo[2,3-b]pyridin-1-yl}-propyl ester(729609-97-6)
• EPA Substance Registry System: methanesulfonic acid 3-{3-[4-(2-chloro-phenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-pyrrolo[2,3-b]pyridin-1-yl}-propyl ester(729609-97-6)

Safety Data

• Hazardous Substances Data: 729609-97-6(Hazardous Substances Data)

Upstream product

• 626604-78-2 {1-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-oxo-acetic acid methyl ester 
• 357263-49-1 methyl α-oxo-1H-pyrrolo[2,3-b]pyridine-3-acetate 
• 124-63-0 methanesulfonyl chloride 
• 626603-93-8 3-(2-chlorophenyl)-4-[1-(3-hydroxypropyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-1H-pyrrole-2,5-dione 
• 271-63-6 7-Azaindole 

Relevant articles and documents

3-(7-Azaindolyl)-4-arylmaleimides as potent, selective inhibitors of glycogen synthase kinase-3

A novel series of acyclic 3-(7-azaindolyl)-4-(aryl/heteroaryl)maleimides was synthesized and evaluated for activity against GSK-3β and selectivity versus PKC-βII, as well as a broad panel of protein kinases. Compounds 14 and 17c potently inhibited GSK-3β (IC50=7 and 26nM, respectively) and exhibited excellent selectivity over PKC-βII (325 and >385-fold, respectively). Compound 17c was also highly selective against 68 other protein kinases. In a cell-based functional assay, both 14 and 17c effectively increased glycogen synthase activity by inhibiting GSK-3β.