72985-21-8

Basic information

• Product Name: 5-(hydroxymethyl)-2-methylbenzoic acid
• Synonyms: 5-(hydroxymethyl)-2-methylbenzoic acid
• CAS NO: 72985-21-8
• Molecular Weight: 166.177
• Mol File: 72985-21-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 359.1±30.0 °C(Predicted)
• Density: 1.258±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 5-(hydroxymethyl)-2-methylbenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(hydroxymethyl)-2-methylbenzoic acid(72985-21-8)
• EPA Substance Registry System: 5-(hydroxymethyl)-2-methylbenzoic acid(72985-21-8)

Safety Data

• Hazardous Substances Data: 72985-21-8(Hazardous Substances Data)

Upstream product

• 118-90-1 ortho-methylbenzoic acid 
• 104-87-0 4-methyl-benzaldehyde 
• 36276-24-1 3-bromo-4-methyl-benzaldehyde 
• 124-38-9 carbon dioxide 
• 68120-35-4 (3-bromo-4-methyl-phenyl)-methanol 
• 610-72-0 2,5-dimethylbenzoic acid 

Downstream Products

• 675148-96-6 methyl 5-formyl-2-methylbenzoate 
• 72985-24-1 methyl 5-(hydroxymethyl )-2-methylbenzoate 
• 105650-34-8 5-formyl-2-methylbenzoic acid 
• 72985-28-5 3,5'-Bis(methoxymethyl)-2'-methyldeoxybenzoin trimethylene dithioketal 
• 72985-00-3 3,5'-Bis(brommethyl)-2'-methyldeoxybenzoin trimethylene dithioketal 
• 72984-98-6 3,5'-Bis(methoxymethyl)-2'-methyldeoxybenzoin 
• 72984-99-7 3,5'-Bis(bromomethyl)-2'-methyldeoxybenzoin 
• 72985-25-2 Methyl-5-(methoxymethyl)-2-methylbenzoate 
• 72985-26-3 5-(Methoxymethyl)-2-methylbenzyl alcohol 
• 72985-27-4 5-(Methoxymethyl)-2-methylbenzyl bromide 

Relevant articles and documents

Novel S1P1 receptor agonists - Part 4: Alkylaminomethyl substituted aryl head groups

In a previous communication we reported on the discovery of alkylamino pyridine derivatives (e.g. 1) as a new class of potent, selective and efficacious S1P1 receptor (S1PR1) agonists. However, more detailed profiling revealed that this compound class is phototoxic in vitro. Here we describe a new class of potent S1PR1 agonists wherein the exocyclic nitrogen was moved away from the pyridine ring (e.g. 11c). Further structural modifications led to the identification of novel alkylaminomethyl substituted phenyl and thienyl derivatives as potent S1PR1 agonists. These new alkylaminomethyl aryl compounds showed no phototoxic potential. Based on their in vivo efficacy and ability to penetrate the brain, the 5-alkyl-aminomethyl thiophenes appeared to be the most interesting class. Potent and selective S1PR1 agonist 20e, for instance, maximally reduced the blood lymphocyte count (LC) for 24 h after oral administration of 10 mg/kg to rat and its brain concentrations reached >500 ng/g over 24 h.

OLEFIN SUBSTITUTED OXINDOLES HAVING AMPK ACTIVITY

The present invention relates to compounds of formula (I), which have valuable pharmacological properties, in particular are activators of AMPK and which are therefore useful in the treatment of certain disorders that can be prevented or treated by activation of this receptor. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.

HIV protease inhibitors

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