730237-52-2 Usage
General Description
1-Methylindole-3-carboxamidine is a chemical compound that is a derivative of indole. It is a carboxamidine, which is a functional group containing a carbon atom double-bonded to a nitrogen atom and single-bonded to an amidine group. 1-METHYLINDOLE-3-CARBOXAMIDINE is often used in organic synthesis and pharmaceutical research as a building block for creating other compounds or as a starting material for the production of drugs. It has potential applications in the development of new medications due to its unique chemical properties and structure.
Check Digit Verification of cas no
The CAS Registry Mumber 730237-52-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,3,0,2,3 and 7 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 730237-52:
(8*7)+(7*3)+(6*0)+(5*2)+(4*3)+(3*7)+(2*5)+(1*2)=132
132 % 10 = 2
So 730237-52-2 is a valid CAS Registry Number.
730237-52-2Relevant articles and documents
Route to 3-Amidino Indoles via Pd(II)-Catalyzed C-H Bond Activation
Rydfjord, Jonas,Skillinghaug, Bobo,Brandt, Peter,Odell, Luke R.,Larhed, Mats
, p. 4066 - 4069 (2017)
We report a facile synthesis of 3-amidino indoles from indoles and cyanamides. The reaction is Pd(II)-catalyzed and proceeds via C-H bond activation of the indole in its 3-position followed by a 1,2-addition of the resulting indole-palladium σ-complex to a cyanamide, which provides the corresponding amidine. The preference for 4,5-diazafluoren-9-one (DAF) as the ligand is investigated using DFT calculations, and a plausible reaction pathway is presented.
