73028-21-4Relevant articles and documents
Excitatory Amino Acids. Improved Synthesis of Ibotenic Acid and X-Ray Analysis of an Unexpected Reaction Product, (RS)-N--3-oxobutyramide
Madsen, Ulf,Brehm, Lotte,Krogsgaard-Larsen, Povl
, p. 359 - 364 (2007/10/02)
A new synthesis of the excitotoxic natural product ibotenic acid (1) is described.Benzylation of 3-hydroxy-5-methylisoxazole (5) yielded 3-benzyloxy-5-methylisoxazole (7) and the isomeric isoxazol-3(2H)-one (6).While metallation of compound (7) by lithium