7304-32-7 Usage
Description
2-Fluoro-5-nitrobenzoic acid is an organic compound characterized by the presence of a fluorine atom at the 2nd position and a nitro group at the 5th position on a benzene ring, with a carboxylic acid functional group. It is a versatile building block in organic synthesis and has potential applications in the pharmaceutical and chemical industries.
Uses
Used in Pharmaceutical Synthesis:
2-Fluoro-5-nitrobenzoic acid is used as a key intermediate in the synthesis of various pharmaceutical compounds, including dibenz[b,f]oxazepin-11(10H)-ones and substituted dibenzazocines. It is utilized in the nucleophilic aromatic substitution (SNAr) reaction with the hydroxyl (OH) group of various 2-aminophenols and immobilized polysubstituted phenols on solid support, enabling the formation of these complex heterocyclic structures.
Used in Chemical Synthesis:
2-Fluoro-5-nitrobenzoic acid is employed as a starting material in the synthesis of oxazepines, a class of heterocyclic compounds with potential applications in various chemical and pharmaceutical processes. Its reactivity and functional group compatibility make it a valuable component in the development of new chemical entities and materials.
Check Digit Verification of cas no
The CAS Registry Mumber 7304-32-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,3,0 and 4 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 7304-32:
(6*7)+(5*3)+(4*0)+(3*4)+(2*3)+(1*2)=77
77 % 10 = 7
So 7304-32-7 is a valid CAS Registry Number.
InChI:InChI=1/C7H4FNO4/c8-6-2-1-4(9(12)13)3-5(6)7(10)11/h1-3H,(H,10,11)/p-1
7304-32-7Relevant articles and documents
Discovery of novel 2-phenylamino-4-prolylpyrimidine derivatives as TRK/ALK dual inhibitors with promising antitumor effects
Cao, Zhi,Guo, Ming,Jiang, Nan,Li, Changtao,Li, Tong,Wang, Xinyu,Yang, Jing,Zhai, Xin
, (2021/10/06)
In order to explore novel TRK and ALK dual inhibitors, a series of 2-phenylamino-4-prolylpyrimidine derivatives were designed, synthesized and evaluated for their in vitro cytotoxicity and enzymatic activities. Delightfully, most compounds were detected m
New strategy for detection of hydrogen peroxide based on bi-nucleophilic reaction
Liu, Xiang,Mao, Chenxin,Tian, Yafei,Wang, Bei,Wang, Shuoshuo
supporting information, (2021/07/14)
Two novel fluorescent probes based on 7-hydroxy-4-methyl-coumarin, FAA-MC-OH (2-fluoro-4-nitro-phenylacetyl hydroxyl coumarin) and FBA-MC-OH (2-fluoro-4-nitro-benzoyl hydroxyl coumarin) are first synthesized, and spectral studies confirm that both the pro
2-HYDROXYISOQUINOLINE-1,3(2H,4H)-DIONES AND RELATED COMPOUNDS USEFUL AS HIV REPLICATION INHIBITORS
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Page/Page column 83, (2012/07/13)
The present invention relates to compounds and compositions acting as inhibitors of HIV integrase. The compound of the invention is of Formula (I), or a tautomer (I') thereof, or a pharmaceutically acceptable salt, or solvate of said compound or tautomer
