730980-59-3

Basic information

• Product Name: (R)-CHROMAN-4-YLAMINE HYDROCHLORIDE
• Synonyms: (R)-CHROMAN-4-YLAMINE HYDROCHLORIDE;2H-1-Benzopyran-4-amine, 3,4-dihydro-, hydrochloride, (4R)- (9CI);(R)-chroman-4-amine hydrochloride;(4R)-3,4-DIHYDRO-2H-1-BENZOPYRAN-4-AMINE HCl;(R)-4-Aminochromane Hydrochloride
• CAS NO: 730980-59-3
• Molecular Formula: C₉H₁₁NO*ClH
• Molecular Weight: 185.65
• Mol File: 730980-59-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: (R)-CHROMAN-4-YLAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-CHROMAN-4-YLAMINE HYDROCHLORIDE(730980-59-3)
• EPA Substance Registry System: (R)-CHROMAN-4-YLAMINE HYDROCHLORIDE(730980-59-3)

Safety Data

• Hazardous Substances Data: 730980-59-3(Hazardous Substances Data)

Usage

Description

(R)-CHROMAN-4-YLAMINE HYDROCHLORIDE is an organic compound with the molecular formula C9H12ClNO and is characterized by its unique chemical structure. It is a chiral molecule, with the R-configuration indicating the specific arrangement of atoms in its structure. (R)-CHROMAN-4-YLAMINE HYDROCHLORIDE has been identified for its potential applications in various fields, particularly in the pharmaceutical and chemical industries.

Uses

Used in Pharmaceutical Industry:
(R)-CHROMAN-4-YLAMINE HYDROCHLORIDE is used as a key intermediate in the synthesis of inhibitors of apoptosis proteins (IAP) antagonists. These antagonists are designed to target and inhibit the activity of IAPs, which are proteins that play a crucial role in regulating cell survival and apoptosis (programmed cell death). By inhibiting IAPs, these antagonists can promote apoptosis in cancer cells, making them potential therapeutic agents for the treatment of various types of cancer.
(R)-CHROMAN-4-YLAMINE HYDROCHLORIDE is used as a building block for the development of novel tricyclic compounds. These compounds are also designed to act as IAP antagonists, offering an alternative approach to targeting IAPs in cancer treatment. The unique chemical structure of these tricyclic compounds may provide improved potency, selectivity, or pharmacokinetic properties compared to existing IAP inhibitors.
Used in Chemical Research:
In addition to its applications in the pharmaceutical industry, (R)-CHROMAN-4-YLAMINE HYDROCHLORIDE may also be utilized in chemical research for the development of new compounds with potential applications in various fields. Its unique structure and reactivity make it a valuable starting material for the synthesis of a wide range of organic compounds, including those with potential biological, pharmaceutical, or materials science applications.

Upstream product

• 730980-58-2 2-methoxy-N-((R)-3,4-dihydro-2H-chromen-4-yl)acetamide 

Downstream Products

• 1266230-01-6 tert-butyl [(1S)-2-({(1S)-1-cyclohexyl-2-[(3S,8aR)-3-[(4R)-3,4-dihydro-2H-cromen-4-ylcarbamoyl] hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-oxoethyl}amino)-1-methyl-2-oxoethyl]methylcarbamate 
• 1266230-55-0 tert-butyl [(1S)-2-({(1S)-1-cyclohexyl-2-[(3S,7R,8aR)-3-[(4R)-3,4-dihydro-2H-chromen-4-ylcarbamoyl]-7-hydroxyhexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-oxoethyl}amino)-1-methyl-2-oxoethyl]methylcarbamate 
• 1266230-60-7 tert-butyl [(1S)-2-({(1S)-1-cyclohexyl-2-[(3S,7R,8aR)-3-[(4R)-3,4-dihydro-2H-chromen-4-ylcarbamoyl]-7-hydroxy-7-methylhexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-oxoethyl}amino)-1-methyl-2-oxoethyl]methylcarbamate 
• 1266230-62-9 tert-butyl {(1S)-1-cyclohexyl-2-[(3S,8aR)-3-[(4R)-3,4-dihydro-2H-chromen-4-ylcarbamoyl]-7,7-dimethoxyhexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-oxoethyl}carbamate 
• 1266230-93-6 tert-butyl [(1S)-2-({(1S)-1-cyclohexyl-2-[(3S,8aR)-3-[(4R)-3,4-dihydro-2H-chromen-4-ylcarbamoyl]hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-oxoethyl}amino)-1-methyl-2-oxoethyl]ethylcarbamate 
• 1266230-97-0 tert-butyl [(1S)-2-({(1S)-1-cyclohexyl-2-[(3S,8aR)-3-[(4R)-3,4-dihydro-2H-chromen-4-ylcarbamoyl]-7,7-difluorohexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-oxoethyl}amino)-1-methyl-2-oxoethyl]methylcarbamate 

Relevant articles and documents

INHIBITOR OF APOPTOSIS (IAP) PROTEIN ANTAGONISTS

Provided herein are compounds that modulate the activity of melanoma inhibitor of apoptosis (ML-IAP) protein, compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.