73151-29-8

Basic information

• Product Name: Fenticonazole nitrate
• Synonyms: 1-[2-(2,4-dichlorophenyl)-2-[[4-(phenylthio)phenyl]methoxy]ethyl]-1H-imidazole,nitrate (1:1);1-(2-(2,4-DICHLOROPHENYL)-2-((4-(PHENYLTHIO)BENZYL)OXY)ETHYL)-1H-IMIDAZOLE;FENTICONAZOLE NITRATE;1-[2-(2,4-dichlorophenyl)-2-[[4-(phenylthio)phenyl]methoxy]ethyl]-1H-imidazolium nitrate;Fenticonazol Nitrate;1-[2-(2,4-Dichlorophenyl)-2-[(4-phenylsulfanylphenyl)methoxy]ethyl]imidazole nitrate;1-[2-(2，4-Dichlorophenyl)-2-[[4-(phenylthio)phenyl]methoxy]ethyl]-1H-imidazole mononitrate;Falvin
• CAS NO: 73151-29-8
• Molecular Formula: C24H21Cl2N3O4S
• Molecular Weight: 518.41
• EINECS: 277-302-6
• Product Categories: Inhibitors;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 73151-29-8.mol
• Article Data: 0

Chemical Properties

• Melting Point: 135-137°C
• Boiling Point: 637.2oC at 760 mmHg
• Flash Point: 339.2oC
• Appearance: /
• Density: 1.26g/cm3
• Vapor Pressure: 1.93E-15mmHg at 25°C
• Refractive Index: 1.632
• Storage Temp.: Refrigerator
• Solubility: Practically insoluble in water, freely soluble in dimethylformamide and in methanol, sparingly soluble in anhydrous ethanol
• PKA: 6.54(at 25℃)
• Merck: 14,4005
• CAS DataBase Reference: Fenticonazole nitrate(CAS DataBase Reference)
• NIST Chemistry Reference: Fenticonazole nitrate(73151-29-8)
• EPA Substance Registry System: Fenticonazole nitrate(73151-29-8)

Safety Data

• RTECS: NI4780000
• Hazardous Substances Data: 73151-29-8(Hazardous Substances Data)

Usage

Description

Fenticonazole nitrate is an antifungal imidazole derivative that is more effective than other imidazole antifungals such as miconazole, clotrimazole, and econazole. It exhibits potent, broad-spectrum fungicidal activity and is also active against some Gram-positive bacteria. Fenticonazole is a racemate comprising equimolar amounts of (R)and (S)-fenticonazole nitrate, and it is used for the treatment of vaginal candidiasis. It is an off-white solid and is available under the brand name Lomexin.

Uses

Used in Pharmaceutical Industry:
Fenticonazole nitrate is used as a broad-spectrum antimycotic for the treatment of various fungal infections. It is particularly effective against clinical isolates of Candida species, including C. albicans, C. parapsilosis, C. tropicalis, C. krusei, and C. guilliermondii, with MIC values ranging from 0.12 to 32 μg/ml.
Fenticonazole nitrate is also used as an antibacterial agent for the treatment of bacterial infections, including bacterial vaginosis caused by B. fragilis (MICs = ≤0.03-16 μg/ml) and skin infections caused by bacteria such as S. aureus and S. epidermidis, with MIC values ranging from 0.03 μg/ml or less to greater than 16 μg/ml.
Used in Veterinary Medicine:
Fenticonazole nitrate is used as an antifungal agent in a guinea pig model of experimental M. canis dermatomycosis, with an ED50 of 0.5% when applied topically.
Used in Gynecological Applications:
Fenticonazole nitrate is used as a treatment for vaginal candidiasis, providing effective relief from symptoms and promoting the recovery of healthy vaginal flora.

Therapeutic Function

Antifungal

InChI:InChI=1/C24H20Cl2N2OS/c25-19-8-11-22(23(26)14-19)24(15-28-13-12-27-17-28)29-16-18-6-9-21(10-7-18)30-20-4-2-1-3-5-20/h1-14,17,24H,15-16H2