731746-84-2 Usage
Explanation
This is the chemical name of the compound, also known as histidine.
Explanation
Histidine cannot be synthesized by the human body and must be obtained through diet or supplements.
Explanation
Histidine is one of the 20 standard amino acids that make up proteins in living organisms.
Explanation
Histidine is a precursor to histamine, a compound involved in various physiological processes such as immune response and digestion.
Explanation
Histidine is involved in the synthesis of metalloproteins, which are proteins containing metal ions.
Explanation
Histidine plays a role in the transmission of nerve signals in the nervous system.
Explanation
Histidine helps to maintain the pH balance in the body, ensuring proper functioning of enzymes and other biological processes.
Explanation
Histidine is found in high concentrations in hemoglobin, the protein responsible for transporting oxygen in the blood.
Explanation
Histidine is essential for the transport and utilization of iron in the body, which is necessary for various biological processes such as oxygen transport and enzyme function.
Explanation
Histidine is a key component of carnosine, a dipeptide that acts as a buffer against the build-up of lactic acid during high-intensity exercise.
Classification
Essential amino acid
Proteinogenic
One of the 23 proteinogenic amino acids
Biological processes
Precursor for histamine
Involvement
Synthesis of metalloproteins
Role
Neurotransmission
Function
Immune response
pH balance
Maintaining the body's pH balance
Growth and repair
Tissue growth and repair
Hemoglobin concentration
High concentrations in hemoglobin
Iron transport and utilization
Crucial for iron transport and utilization
Carnosine component
Key component of carnosine
Check Digit Verification of cas no
The CAS Registry Mumber 731746-84-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,3,1,7,4 and 6 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 731746-84:
(8*7)+(7*3)+(6*1)+(5*7)+(4*4)+(3*6)+(2*8)+(1*4)=172
172 % 10 = 2
So 731746-84-2 is a valid CAS Registry Number.
731746-84-2Relevant articles and documents
Discovery of α-Substituted Imidazole-4-acetic Acid Analogues as a Novel Class of ρ1γ-Aminobutyric Acid Type A Receptor Antagonists with Effect on Retinal Vascular Tone
Krall, Jacob,Brygger, Benjamin M.,Sigureardóttir, Sara B.,Ng, Clarissa K. L.,Bundgaard, Christoffer,Kehler, Jan,Nielsen, Birgitte,Bek, Toke,Jensen, Anders A.,Fr?lund, Bente
, p. 2299 - 2310 (2016/10/25)
The ρ-containing γ-aminobutyric acid type A receptors (GABAARs) play an important role in controlling visual signaling. Therefore, ligands that selectively target these GABAARs are of interest. In this study, we demonstrate that the partial GABAAR agonist imidazole-4-acetic acid (IAA) is able to penetrate the blood–brain barrier in vivo; we prepared a series of α- and N-alkylated, as well as bicyclic analogues of IAA to explore the structure–activity relationship of this scaffold focusing on the acetic acid side chain of IAA. The compounds were prepared via IAA from l-histidine by an efficient minimal-step synthesis, and their pharmacological properties were characterized at native rat GABAARs in a [3H]muscimol binding assay and at recombinant human α1β2γ2Sand ρ1GABAARs using the FLIPR membrane potential assay. The (+)-α-methyl- and α-cyclopropyl-substituted IAA analogues ((+)-6 a and 6 c, respectively) were identified as fairly potent antagonists of the ρ1GABAAR that also displayed significant selectivity for this receptor over the α1β2γ2SGABAAR. Both 6 a and 6 c were shown to inhibit GABA-induced relaxation of retinal arterioles from porcine eyes.
