73177-96-5

Basic information

• Product Name: <(hydroxy)(tosyloxy)iodo>-p-toluene
• Synonyms: <(hydroxy)(tosyloxy)iodo>-p-toluene
• CAS NO: 73177-96-5
• Molecular Weight: 406.241
• Mol File: 73177-96-5.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: <(hydroxy)(tosyloxy)iodo>-p-toluene(CAS DataBase Reference)
• NIST Chemistry Reference: <(hydroxy)(tosyloxy)iodo>-p-toluene(73177-96-5)
• EPA Substance Registry System: <(hydroxy)(tosyloxy)iodo>-p-toluene(73177-96-5)

Safety Data

• Hazardous Substances Data: 73177-96-5(Hazardous Substances Data)

Upstream product

• 624-31-7 4-tolyl iodide 
• 27126-76-7 [hydroxy(tosyloxy)iodo]benzene 
• 69180-59-2 1-iodosyl-4-methylbenzene 
• 104-15-4 toluene-4-sulfonic acid 
• 16308-16-0 1-(diacetoxyiodo)-4-methylbenzene 
• 371-11-9 4-(difluoroiodo)toluene 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 108-88-3 toluene 
• 71-43-2 benzene 

Downstream Products

• 85925-55-9 (2-Furyl)(4-methylphenyl)iodonium Tosylate 
• 85925-41-3 Toluene-4-sulfonate(5-methyl-furan-2-yl)-p-tolyl-iodonium; 
• 85925-24-2 Toluene-4-sulfonatep-tolyl-(5-trimethylsilanyl-furan-2-yl)-iodonium; 
• 73177-95-4 4-methylphenyl(phenyl)iodonium tosylate 
• 175348-71-7 3-(p-tolyliodonio)-1,4-naphthoquinone-2-imide 
• 98475-04-8 1-(4-methylphenyl)-2-(p-tolylsulfonyloxy)ethanone 
• 87456-64-2 α-tosyloxypropiophenone 
• 1382355-02-3 (2-(2-(t-butoxycarbonylamino)ethyl)phenyl)(p-tolyl)iodonium p-toluenesulfonate 
• 1382355-12-5 (2-(2-(benzyloxycarbonylamino)ethyl)phenyl)(p-tolyl)iodonium p-toluenesulfonate 
• 1382355-22-7 (2-(2-acetamidoethyl)phenyl)(p-tolyl)iodonium p-toluenesulfonate 
• 1382355-32-9 (2-(2-(3,3-diethylureido)ethyl)phenyl)(p-tolyl)iodonium p-toluenesulfonate 
• 1428064-59-8 2,4-dimethoxyphenyl(4-methylphenyl)iodonium tosylate 
• 3402-74-2 4-(4-nitrophenoxy)toluene 
• 1579-40-4 1,1'-oxybis(4-methyl-benzene) 

Relevant articles and documents

First hypervalent iodine(III)-catalyzed C-N bond forming reaction: Catalytic spirocyclization of amides to N-fused spirolactams

A protic solvent, 2,2,2-trifluoroethanol (CF3CH2OH), was successfully introduced into hypervalent iodine(iii)-involved catalytic cycles as an effective solvent, and the first iodoarene-catalyzed intramolecular carbon-nitrogen bond forming reaction was achieved under strong acid-free and mild conditions. The Royal Society of Chemistry.

Aryl naproxen derivative high-valence iodine compound, preparation method and application thereof

The invention discloses an aryl naproxen derivative high-valence iodine compound, a preparation method and application thereof, wherein a series of naproxen derivatives are prepared through preparation and derivatization of naproxen high-valence iodine co

A Potential PET Radiotracer for the 5-HT2C Receptor: Synthesis and in Vivo Evaluation of 4-(3-[18F]fluorophenethoxy)pyrimidine

The serotonin 2C receptor subtype (5-HT2C) is an excitatory 5-HT receptor widely distributed throughout the central nervous system. As the 5-HT2C receptor displays multiple actions on various neurotransmitter systems including glutamate, dopamine, epinephrine, and γ-aminobutyric acid (GABA), abnormalities of the 5-HT2C receptor are associated with psychiatric diseases such as depression, schizophrenia, drug abuse, and anxiety. Up to date, three kinds of 5-HT2C PET radiotracers such as [11C]N-methylated arylazepine (1), [11C]WAY-163909 (2), and [18F]fluorophenylcyclopropane (3) have been developed, but they may not be suitable for in vivo 5-HT2C imaging study due to their modest specific binding. Herein, the synthesis and in vivo evaluation of 4-(3-[18F]fluorophenethoxy)pyrimidine [18F]4 as a potential PET radiotracer for the 5-HT2C receptor is described. [18F]4 was synthesized by nucleophilic aromatic substitution of diaryliodonium precursor 17a with a 7.8 ± 2.7% (n = 6, decay corrected) radiochemical yield and over 99% radiochemical purity, showing an 89 ± 14 GBq/μmol specific radioactivity. The in vivo PET imaging studies of [18F]4 with or without lorcaserin, a U.S. Food and Drug Administration approved selective 5-HT2C agonist, demonstrated that [18F]4 exhibits a high level of specific binding to 5-HT2C receptors in the rat brain.