731851-85-7

Basic information

• Product Name: 5-trifluoroacetyl-5,11-dihydro-dibenzo[b,f]azepin-10-one
• Synonyms: 5-trifluoroacetyl-5,11-dihydro-dibenzo[b,f]azepin-10-one
• CAS NO: 731851-85-7
• Molecular Weight: 305.256
• Mol File: 731851-85-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-trifluoroacetyl-5,11-dihydro-dibenzo[b,f]azepin-10-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-trifluoroacetyl-5,11-dihydro-dibenzo[b,f]azepin-10-one(731851-85-7)
• EPA Substance Registry System: 5-trifluoroacetyl-5,11-dihydro-dibenzo[b,f]azepin-10-one(731851-85-7)

Safety Data

• Hazardous Substances Data: 731851-85-7(Hazardous Substances Data)

Upstream product

• 731851-81-3 {2-[Phenyl-(2,2,2-trifluoro-acetyl)-amino]-phenyl}-acetic acid 

Downstream Products

• 28721-07-5 oxcarbazepine 
• 21737-58-6 10,11-dihydro-5H-dibenzo[b,f]azepin-10-one 

Relevant articles and documents

A new synthesis of oxcarbazepine using a Friedel-Crafts cyclization strategy

A novel, simple, and straightforward process for the large-scale synthesis of oxcarbazepine, the active ingredient of Trileptal, a medicine for the treatment of epilepsy, has been developed. Starting from readily available 1,3-dihydro-1-phenyl-2H-indol-2-one, a Friedel-Crafts cyclization strategy provides a direct route to the tricyclic framework of the target molecule. Crucial to the success of the strategy was the choice of the proper nitrogen-protecting group.