73202-52-5

Basic information

• Product Name: 5,8-dihydroxy-6,7-dimethoxy-2-phenyl-4H-chromen-4-one
• Synonyms: 5,8-Dihydroxy-6,7-dimethoxyflavone
• CAS NO: 73202-52-5
• Molecular Formula: C₁₇H₁₄O₆
• Molecular Weight: 314.2895
• Mol File: 73202-52-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 571.7°C at 760 mmHg
• Flash Point: 214.8°C
• Density: 1.402g/cm³
• Vapor Pressure: 1.13E-13mmHg at 25°C
• Refractive Index: 1.645
• CAS DataBase Reference: 5,8-dihydroxy-6,7-dimethoxy-2-phenyl-4H-chromen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5,8-dihydroxy-6,7-dimethoxy-2-phenyl-4H-chromen-4-one(73202-52-5)
• EPA Substance Registry System: 5,8-dihydroxy-6,7-dimethoxy-2-phenyl-4H-chromen-4-one(73202-52-5)

Safety Data

• Hazardous Substances Data: 73202-52-5(Hazardous Substances Data)

Upstream product

• 740-33-0 mosloflavone 
• 169130-05-6 8-benzyloxy-5-hydroxy-6,7-dimethoxyflavone 
• 491-67-8 5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one 

Downstream Products

• 73213-15-7 5,8-diacetoxy-6,7-dimethoxy-2-phenyl-chromen-4-one 
• 3162-43-4 5,6,7,8-tetrahydroxyflavone tetramethyl ether 
• 727409-30-5 5,6,7,8-tetrahydroxyflavone 

Relevant articles and documents

Structure-activity relationships for α-glucosidase inhibition of baicalein, 5,6,7-trihydroxyflavone: The effect of A-ring substitution

In order to estimate the effects of the A-ring hydroxyl group of baicalein (5,6,7-trihydroxyflavone, 1) on rat intestinal α-glucosidase inhibition, flavone, monohydroxyflavones, dihydroxyflavones, and methylated derivatives of 5,6,7-trihydroxyflavone were used for the structure-activity relationship (SAR) study. The importance of the 6-hydroxyl group of baicalein was validated for an exertion of the activity. And also, the tested flavones which lacked a hydroxyl substituent on any of positions 5, 6, or 7, showed no activity. Hence, the 5,6,7-trihydroxyflavone structure was concluded to be crucial for the potent inhibitory activity. In addition, an introduction of electron-withdrawing or electron-donating groups at position 8 of baicalein led to a dramatic decrease for activity, except for 8-fluoro-5,6,7-trihydroxyflavone, which carried a less bulky substituent on position 8. Hence, this result suggested that a sterically bulky substituent on C-8 of baicalein was detrimental for the activity regardless of its electronic nature. Through examining the inhibitory mechanism of baicalein against rat intestinal α-glucosidase, it was suggested to be a mixed type inhibition.

Synthesis of flavones which are cytotoxic against L1210 cells

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