7324-11-0

Basic information

• Product Name: L-2-Aminobutanamide
• Synonyms: L-A-AMINOBUTANAMIDE.HCL;L-2-AMINO-BUTYRAMIDE;L-2-Amino-n-butanamide;(S)-2-Aminobutyramide;L-2-Aminobutanamide;(S)-2-Aminobutanamide;methyl (S)-2-(2-oxopyrrolidin-1-yl)butanoate;Levetiracetam Impurity F
• CAS NO: 7324-11-0
• Molecular Formula: C₄H₁₀N₂O
• Molecular Weight: 102.14
• Mol File: 7324-11-0.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 246 ºC
• Flash Point: 102 ºC
• Appearance: /
• Density: 1.027
• Storage Temp.: 2-8°C(protect from light)
• PKA: 16.07±0.50(Predicted)
• CAS DataBase Reference: L-2-Aminobutanamide(CAS DataBase Reference)
• NIST Chemistry Reference: L-2-Aminobutanamide(7324-11-0)
• EPA Substance Registry System: L-2-Aminobutanamide(7324-11-0)

Safety Data

• Hazardous Substances Data: 7324-11-0(Hazardous Substances Data)

Usage

General Description

L-2-Aminobutanamide, also known as 2-Amino-Butyramide or L-2-Aminobutyramide, is a fundamentally important raw material in organic and medicinal chemistry. This organic compound is composed of carbon, hydrogen, and nitrogen, and it appears as white crystals. It has a broad scope of applications; primarily, it is used as a building block in the synthesis of complex molecules and pharmaceutical intermediates, thereby playing a vital role in drug discovery and medicinal research. Its use and handling require careful safety measures due to its potential hazardous effects.

Upstream product

• 53726-14-0 (S)-2-amino-butanamide hydrochloride 
• 2835-81-6 2-aminobutanoic acid 
• 40651-89-6 2-aminobutyronitrile 
• 4510-08-1 L-methioninamide 
• 2483-62-7 (S)-2-aminobutyric acid methyl ester 
• 53726-14-0 DL-2-aminobutanamide 
• 5959-29-5 S-(+)-2-amino-n-butyric acid hydrochloride 
• 7682-18-0 (S)-2-aminobutyric acid methyl ester hydrochloride 

Downstream Products

• 102767-31-7 (S)-2-(4-chlorobutyramido)butanamide 
• 102767-28-2 levetiracetam 
• 357336-20-0 brivaracetam 
• 357336-99-3 ((2S)-2-[(4S)-2-oxo-4-propyltetrahydro-1H-pyrrol-1-yl]butanamide) 
• 357338-13-7 (2S)-4,5-dehydro-(2-oxo-4-n-propyl-1-pyrrolidinyl)-2-butanamide 
• 1076190-08-3 (2S)-2-{[(benzylamino)acetyl]amino}butanamide 
• 1076190-33-4 methyl 4-{[(1S)-1-(aminocarbonyl)propyl]amino}-3-phenylbutanoate 
• 2483-62-7 (S)-2-aminobutyric acid methyl ester 
• 53726-14-0 (S)-2-amino-butanamide hydrochloride 

Relevant articles and documents

Method for splitting aminobutanamide by using ammonium hydrogen tartrate

The present invention relates to the technical field of aminobutanamide resolution, and discloses a method for resolving aminobutanamide by using ammonium hydrogen tartrate, and the method comprises the following steps: taking 10-20 parts of ammonium tartrate, placing ammonium tartrate in a reaction flask, adding 20-40 parts of purified water, and performing stirring for 0.5-1.5 h to obtain an ammonium tartrate solution. According to the method for resolving aminobutanamide by using ammonium hydrogen tartrate, the ammonium hydrogen tartrate is used as a reactant and is subjected to resolution reaction with racemic 2-aminobutanamide, and an L-2-aminobutanamide ammonium hydrogen tartrate wet product obtained after the reaction is reacted with methanol and ammonia gas, so L-2-aminobutanamide and ammonium hydrogen tartrate can be separated out; the L-2-aminobutanamide liquid can be obtained, the ammonium hydrogen tartrate can be converted into the ammonium tartrate solid for recovery and storage, and the L-2-aminobutanamide solid can be used for splitting the aminobutanamide in the next ammonium hydrogen tartrate preparation so as to achieve the recovery and reutilization of the reactants, such that the production cost is reduced, and the low cost purpose is achieved.

PROCESS FOR PREPARING BRIVARACETAM

The present invention relates to a new process for preparing brivaracetam. (Ib)

Preparation method of S-2-aminobutanamide

The invention provides a preparation method of S-2-aminobutanamide, comprising the steps of 1), reacting hydrogen cyanide, ammonia and n-propanal as materials to obtain 2-aminobutanenitrile; 2), separating a reacted liquid of step 1) by means of extraction to obtain an oil phase and a water phase, adding a catalyst and an alkali solution into the oil phase to carrying out hydrolysis, and reacting to obtain hydrolysate; 3), adding an acid or acid aqueous solution into the hydrolysate of step 2), separating to obtain an oil phase and a water phase, and separating the water phase to obtain S-2-aminobutanamide. The hydrogen cyanide, n-propanal and ammonia are reacted as materials to synthesize 2-aminobutanenitrile, the 2-aminobutanenitrile is hydrolyzed to directly obtain a target product, little byproducts are produced in reaction, and the content of the target product is high; little waste water and waste gas are produced in reaction, zero residue is produced, and there is no mass waste salts produced in the sodium cyanide process; the operation is simple, and product yield and purity are high.